Clinical Trials Updated in 2025

NCT04866563 | COMPLETED | PHASE2

108 participants

A Study of Efficacy and Safety of AX-8 in Chronic Cough

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-08-11
Completion:: 2025-06-16

Conditions

Chronic Cough

Interventions

DRUG

No Results Yet

NCT04758507 | COMPLETED | PHASE1/PHASE2

50 participants

Fecal Microbiota Transplantation to Improve Efficacy of Immune Checkpoint Inhibitors in Renal Cell Carcinoma

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-02-18
Completion:: 2024-12-16

Conditions

Renal Cell Carcinoma

Interventions

BIOLOGICAL
OTHER

No Results Yet

NCT04752566 | COMPLETED | PHASE3

57 participants

A Study to Evaluate the Efficacy and Safety of Eculizumab in Guillain-Barré Syndrome

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-03-08
Completion:: 2022-08-03

Conditions

Guillain-Barre Syndrome

Interventions

BIOLOGICAL
DRUG

Results Available

NCT04728113 | COMPLETED | NA

162 participants

Early Integration of Supportive Care for Metastatic Uveal Melanoma Patients (EarlyTogether)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-07-16
Completion:: 2025-01-22

Conditions

Uveal Melanoma

Interventions

OTHER

No Results Yet

NCT04726592 | TERMINATED | PHASE3

323 participants

Efficacy of CLORazepate for the Treatment of MIGraine Attack in the Emergency Room

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-07-08
Completion:: 2024-04-10

Conditions

Migraine
Migraine Without Aura
Migraine With Aura
Headache

Interventions

DRUG

No Results Yet

NCT04713085 | COMPLETED | NA

48 participants

Sacral Neuromodulation in Children and Adolescents

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-01-01
Completion:: 2024-12-31

Conditions

Chronic Constipation With Overflow
Encopresis With Constipation and Overflow Incontinence
Hirschsprung's Disease
Anorectal Malformations
Sacral Dysgenesis

Interventions

DEVICE

No Results Yet

NCT04710264 | COMPLETED

137 participants

Aurora Test for Patients Treated With Recombinant Gonadotropins

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-02-15
Completion:: 2023-12-31

Conditions

Infertility

Interventions

OTHER

No Results Yet

NCT04653012 | RECRUITING | NA

50 participants

Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-02-28
Completion:: 2029-02-27

Conditions

Focal Epilepsy
Electrodes, Implanted
Cognitive Function
Neurophysiology

Interventions

DEVICE

No Results Yet

NCT04649645 | COMPLETED | NA

460 participants

Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-10-18
Completion:: 2024-12-19

Conditions

Gingivitis
Periodontal Diseases

Interventions

OTHER

No Results Yet

NCT04646005 | COMPLETED | PHASE2

113 participants

Cemiplimab and ISA101b Vaccine in Adult Participants With Recurrent/Metastatic Human Papillomavirus (HPV)16 Cervical Cancer Who Have Experienced Disease Progression After First Line Chemotherapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-06-28
Completion:: 2023-05-22

Conditions

Cervical Cancer

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04630808 | COMPLETED | PHASE3

696 participants

MRCT Evaluating NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-11-09
Completion:: 2025-04-11

Conditions

Open Angle Glaucoma
Ocular Hypertension

Interventions

DRUG

No Results Yet

NCT04583618 | COMPLETED | PHASE2

750 participants

Study of a Pneumococcal Conjugate Vaccine in Adults Aged 50 to 84 Years.

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-10-08
Completion:: 2021-08-09

Conditions

Pneumococcal Immunization

Interventions

BIOLOGICAL

Results Available

NCT04552002 | COMPLETED | PHASE3

64 participants

The Effect of Synbiotic Consumption on Glycemic, Inflammatory Markers and Body Composition on Prediabetic and Diabetic Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-01-06
Completion:: 2025-04-20

Conditions

Dietary Supplements

Interventions

DIETARY_SUPPLEMENT

No Results Yet

NCT04534075 | COMPLETED | PHASE3

354 participants

Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-09-02
Completion:: 2024-09-14

Conditions

Malignant Neoplasm
Malignant Neoplasm of Rectum
Malignant Neoplasm of Anus
Malignant Neoplasm of Urinary Bladder
Malignant Neoplasm of Cervix
Malignant Neoplasm of Ovary
Malignant Neoplasm of Prostate
Malignant Neoplasm of Large Intestine
Malignant Neoplasm of Colon
Gynecologic Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT04504071 | ACTIVE_NOT_RECRUITING | PHASE2

30 participants

Dacomitinib in Lung Cancer With Uncommon EGFR Mutations

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-12-08
Completion:: 2022-12-15

Conditions

Non-small Cell Lung Cancer Metastatic
EGF-R Positive Non-Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT04502082 | TERMINATED | PHASE1

8 participants

Study of ET140203 T Cells in Adults With Advanced Hepatocellular Carcinoma (ARYA-1)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-04-14
Completion:: 2024-08-30

Conditions

Hepatocellular Carcinoma
Liver Cancer
Liver Neoplasm
Metastatic Liver Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT04475666 | RECRUITING | NA

2502 participants

Replacing Protein Via Enteral Nutrition in Critically Ill Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-09-21
Completion:: 2025-11-30

Conditions

Critical Illness
Nutrition Disorders

Interventions

OTHER

No Results Yet

NCT04462471 | COMPLETED | PHASE1

8 participants

Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-06-26
Completion:: 2023-09-29

Conditions

Thyroid Carcinoma
Thyroid Cancer
Thyroid Cancer, Follicular
Thyroid Cancer (Follicular Cell)
Thyroid Cancer, Papillary
BRAF V600E Mutation Positive

Interventions

DIAGNOSTIC_TEST
DRUG

Results Available

NCT04410900 | COMPLETED | PHASE1

49 participants

Vaccine Responsiveness After CAR-T Cell Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-08-03
Completion:: 2025-04-28

Conditions

B-Cell Neoplasm

Interventions

BIOLOGICAL
PROCEDURE

No Results Yet

NCT04398706 | COMPLETED | PHASE2

852 participants

Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-05-22
Completion:: 2023-08-10

Conditions

Pneumococcal Immunisation
Diphtheria Immunisation
Tetanus Immunisation
Pertussis Immunisation
Hepatitis B Immunisation
Haemophilus Influenzae Type b Immunisation
Polio Immunisation
Measles Immunisation
Rubella Immunisation
Varicella Immunisation
Mumps Immunisation

Interventions

BIOLOGICAL

Results Available

NCT04389463 | RECRUITING

350 participants

Patient Outcome of Cardiac Surgery During the COVID-19 Pandemic

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-05-11
Completion:: 2026-05-11

Conditions

Patients Undergoing Cardiac or Thoracic Surgery

Interventions

OTHER

No Results Yet

NCT04385290 | RECRUITING | PHASE1/PHASE2

214 participants

Combination of Midostaurin and Gemtuzumab Ozogamicin in First-line Standard Therapy for Acute Myeloid Leukemia (MOSAIC)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-09-04
Completion:: 2027-04-30

Conditions

Acute Myeloid Leukemia

Interventions

DRUG

No Results Yet

NCT04379570 | ACTIVE_NOT_RECRUITING | PHASE3

1167 participants

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-02-15
Completion:: 2026-08-31

Conditions

Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
HER2 Negative Breast Carcinoma
Hormone Receptor Positive Breast Carcinoma
Invasive Breast Carcinoma
Prognostic Stage I Breast Cancer AJCC v8
Prognostic Stage II Breast Cancer AJCC v8
Prognostic Stage III Breast Cancer AJCC v8

Interventions

OTHER
BEHAVIORAL

No Results Yet

NCT04335968 | COMPLETED | PHASE3

357 participants

Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-01-23
Completion:: 2025-04-18

Conditions

Orthopedic Surgery

Interventions

DRUG

No Results Yet

NCT04264260 | COMPLETED | PHASE2

42 participants

Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-12-24
Completion:: 2025-05-30

Conditions

Hepatocellular Carcinoma Stage IIIB
Cholangiocarcinoma, Intrahepatic
Cholangiocarcinoma; With Hepatocellular Carcinoma
Hepatocellular Carcinoma Stage IV

Interventions

DRUG

No Results Yet

NCT04221529 | COMPLETED | PHASE2

70 participants

Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-01-06
Completion:: 2024-04-12

Conditions

SCLC, Extensive Stage

Interventions

DRUG

No Results Yet

NCT04198012 | COMPLETED | NA

25 participants

An Open Label Study to Allow Patients Continuous Use of the HemoCare™ Hemodialysis System

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-12-16
Completion:: 2024-04-05

Conditions

End Stage Renal Disease

Interventions

DEVICE

Results Available

NCT04067011 | COMPLETED | PHASE2

210 participants

Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-08-12
Completion:: 2020-03-05

Conditions

Anthrax

Interventions

DRUG
BIOLOGICAL

Results Available

NCT04046237 | RECRUITING | NA

210 participants

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-08-02
Completion:: 2028-08-31

Conditions

Acute Myocardial Infarction
Severe Periodontitis
Carotid Atherosclerosis

Interventions

OTHER

No Results Yet

NCT04028999 | COMPLETED | NA

25 participants

Implementation of Supportive Sling Device in Adults Post-stroke for Prevention of Shoulder Complications

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-07-03
Completion:: 2023-05-11

Conditions

Cerebrovascular Accident

Interventions

DEVICE

No Results Yet

NCT04017767 | COMPLETED | NA

30 participants

Motor Plasticity, Intermittent Hypoxia and Sleep Apnea

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2021-07-16
Completion:: 2025-07-01

Conditions

Sleep Apnea, Obstructive
Spinal Cord Injuries
Hypoxia

Interventions

PROCEDURE
DEVICE

No Results Yet

NCT03977207 | RECRUITING | NA

336 participants

A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis Patients

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2020-07-20
Completion:: 2025-11-30

Conditions

Thyroid; Functional Disturbance
Hypothyroidism
Hemodialysis

Interventions

DRUG

No Results Yet

NCT03925480 | COMPLETED | PHASE3

2110 participants

Preventing Young Infant Infections Using Azithromycin in Labour (PreYIAL) Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-07-01
Completion:: 2022-05-25

Conditions

Bacterial Infections

Interventions

DRUG

No Results Yet

NCT03746015 | COMPLETED | PHASE2

30 participants

Immunogenicity and Safety of Tetravalent Dengue Vaccine Candidate (TDV) in Flavivirus-Naïve and Dengue-Immune Adults

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2018-12-28
Completion:: 2021-03-01

Conditions

Dengue Fever

Interventions

BIOLOGICAL

Results Available

NCT03737136 | COMPLETED | NA

20 participants

Comparison Between Bortezomib and Rituximab Plus Plasmapheresis in AMR

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2019-11-01
Completion:: 2024-05-30

Conditions

Antibody-mediated Rejection

Interventions

DRUG

No Results Yet

NCT03681145 | COMPLETED | NA

50 participants

Youth to Text or Telehealth for Engagement in HIV Care

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2018-08-15
Completion:: 2019-11-08

Conditions

HIV/AIDS
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Depression
Substance Use

Interventions

BEHAVIORAL

No Results Yet

NCT03591159 | ACTIVE_NOT_RECRUITING | NA

256 participants

The Effect of Membrane Sweeping on the Delivery Time and the Need of Induction in Term Pregnancy

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2018-05-29
Completion:: 2020-01-01

Conditions

Delivery, Obstetric

Interventions

OTHER

No Results Yet

NCT03558789 | COMPLETED

100 participants

Metallic Taste Before, During and After Treatment of Head and Neck Cancer

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-08
Start Date:: 2018-04-26
Completion:: 2022-12-01

Conditions

Metallic Taste

Interventions

BIOLOGICAL

No Results Yet

NCT03531151 | COMPLETED

14 participants

MRI of Myocardial Infarction

Study Type:: OBSERVATIONAL
Last Updated:: 2025-09-08
Start Date:: 2018-04-01
Completion:: 2025-03-31

Conditions

Myocardial Infarction
Myocardial Ischemia
Myocardial Injury
Myocardial Fibrosis
Myocardial Reperfusion Injury
Myocardial Edema
Myocardial Necrosis
Heart Failure
Ischemic Heart Disease
Ischemic Cardiomyopathy
Hemorrhage

No Results Yet

NCT03440801 | COMPLETED | NA

240 participants

A Randomized Comparison of Long-Term Healing Between Biodegradable- Versus Durable-Polymer Everolimus Eluting Stents in STEMI

Study Type:: INTERVENTIONAL
Last Updated:: 2025-09-08
Start Date:: 2017-07-03
Completion:: 2024-07-30

Conditions

STEMI - ST Elevation Myocardial Infarction

Interventions

DEVICE

No Results Yet