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Motor Plasticity, Intermittent Hypoxia and Sleep Apnea

NCT04017767 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-09-08

No results posted yet for this study

Summary

The purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.

Conditions

  • Sleep Apnea, Obstructive
  • Spinal Cord Injuries
  • Hypoxia

Interventions

PROCEDURE

Induced Acute Intermittent Hypoxia (AIH)

AIH will be administered on days 1-3. Each day entails 15 and 90 second hypoxic intervals (Fraction of Inspired Oxygen (FIO2) = 0.09) alternating with 60-second normoxic intervals (FIO2 = 0.21).

DEVICE

AIH mask

Induced Intermitted hypoxia will be delivered via the AIH mask. The mask has two one-way valves restricting inspiration to the top valve and expiration to the bottom valve. Hypoxic and normoxic gas mixtures will be delivered through the top valve.

Sponsors & Collaborators

  • The Craig H. Neilsen Foundation

    collaborator OTHER

  • University of Miami

    lead OTHER

Principal Investigators

  • Shirin Shafazand, MD · University of Miami

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-16
Primary Completion
2025-07-01
Completion
2025-07-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04017767 on ClinicalTrials.gov