Clinical Trials

NCT02925104 | COMPLETED | PHASE1

36 participants

A Dose Escalation Study to Assess PK, Safety and Tolerability of INC280 When Taken With Food in cMET Dysregulated Advanced Solid Tumors.

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2016-12-14

Completion:

2018-05-16

Conditions

• cMET Dysegulation Advanced Solid Tumors

Interventions

• DRUG

No Results Yet

NCT02863016 | COMPLETED

66 participants

Effects of Postdilution Online Hemodiafiltration With AcEtate-free Citrate dialySis Fluid on Inflammation Markers

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2016-07-31

Completion:

2016-08-31

Conditions

• ESRD

Interventions

• DEVICE

No Results Yet

NCT02788214 | TERMINATED

1000 participants

Helicobacter Pylori Genome Project (HpGP)

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2016-07-27

Completion:

2020-05-15

Conditions

• Gastric Cancer
• Non-Atrophic Gastritis
• Intestinal Metaplasia

No Results Yet

NCT02755298 | COMPLETED | PHASE2/PHASE3

24 participants

Chronic Clinical Effect of Acetazolamide

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2016-10-31

Completion:

2020-11-30

Conditions

• Hypertension, Pulmonary

Interventions

• DRUG

No Results Yet

NCT02737696 | COMPLETED | NA

435 participants

Computer-based Prescription Opioid Abuse Prevention for Adolescents

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2017-05-15

Completion:

2018-03-18

Conditions

• Opioid Related Disorders

Interventions

• BEHAVIORAL

No Results Yet

NCT02647762 | TERMINATED | PHASE3

244 participants

CF101 Therapy Compared to Methotrexate Therapy for Active Rheumatoid Arthritis

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2017-10-30

Completion:

2020-11-30

Conditions

• Rheumatoid Arthritis

Interventions

• DRUG

No Results Yet

NCT02636920 | COMPLETED | NA

50 participants

Study and Development of Application Models of "Therapeutic Education to the Patient" (TEP) in Asthmatic Children

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2017-03-01

Completion:

2017-08-31

Conditions

• Asthma

Interventions

• OTHER

No Results Yet

NCT02572570 | TERMINATED | NA

27 participants

Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-12-31

Completion:

2019-12-05

Conditions

• Dental Restoration Failure of Marginal Integrity
• Dental Caries
• Unrepairable Overhanging of Dental Restorative Materials
• Poor Aesthetics of Existing Restoration
• Secondary Dental Caries Associated With Failed or Defective Dental Restorations
• Fractured Dental Restorative Materials Without Loss of Materials
• Fracture of Dental Restorative Materials With Loss of Material

Interventions

• DEVICE

Results Available

NCT02545088 | COMPLETED | NA

48 participants

New Technology for Individualised, Intensive Training of Gait After Stroke- Study II

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-10-31

Completion:

2019-09-30

Conditions

• Stroke
• Ambulation Difficulty
• Hemiparesis

Interventions

• DEVICE
• OTHER

No Results Yet

NCT02502149 | COMPLETED | PHASE3

24 participants

Pharmacokinetics and Safety of rFVIIIFc Manufactured at 15,000 L (15K) Scale

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-08-31

Completion:

2017-04-30

Conditions

• Severe Hemophilia A

Interventions

• BIOLOGICAL

Results Available

NCT02447627 | COMPLETED

38 participants

Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell Disease

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2015-06-30

Completion:

2016-10-31

Conditions

• Healthy
• Sickle Cell Disease

No Results Yet

NCT02431481 | COMPLETED | PHASE1

38 participants

Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-10-23

Completion:

2017-09-14

Conditions

• Normal Renal Function
• Impaired Renal Function

Interventions

• DRUG

No Results Yet

NCT02422589 | COMPLETED | PHASE1

33 participants

A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-10-23

Completion:

2017-12-12

Conditions

• ALK-positive Advanced Tumors

Interventions

• DRUG

No Results Yet

NCT02399202 | COMPLETED | PHASE1

15 participants

A Phase I Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Renal Function

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-11-06

Completion:

2016-03-21

Conditions

• Renal Impairment

Interventions

• DRUG

No Results Yet

NCT02392156 | TERMINATED

3 participants

Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2015-07-31

Completion:

2015-12-31

Conditions

• Hemophilia A
• Hemophilia B

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT02388620 | COMPLETED | PHASE1

30 participants

Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-03-25

Completion:

2017-01-09

Conditions

• Normal Hepatic Function
• Impaired Hepatic Function

Interventions

• DRUG

No Results Yet

NCT02375958 | COMPLETED | PHASE1

47 participants

PCA062 in pCAD-positive Tumors.

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-04-15

Completion:

2018-07-17

Conditions

• Triple Negative Breast Cancer
• Head & Neck Cancer
• Esophageal Cancer

Interventions

• DRUG

No Results Yet

NCT02372084 | COMPLETED | PHASE1

33 participants

A Phase 1 Study of Osilodrostat (LCI699) in Healthy Volunteers and Subjects With Impaired Hepatic Function

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-04-21

Completion:

2016-05-19

Conditions

• Hepatic Impairment

Interventions

• DRUG

No Results Yet

NCT02308020 | COMPLETED | PHASE2

162 participants

A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-04-20

Completion:

2018-11-08

Conditions

• Breast Cancer
• Non-small Cell Lung Cancer
• Melanoma
• Brain Metastases

Interventions

• DRUG

Results Available

NCT02288117 | UNKNOWN

240 participants

Prospective Clinical 5-year Follow-up of the LINK® SP-CL® Hip Prosthesis Stem

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2015-07-31

Completion:

2022-05-31

Conditions

• Osteoarthritis, Hip
• Femur Head Necrosis
• Femoral Neck Fractures

No Results Yet

NCT02244814 | COMPLETED | NA

105 participants

Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2015-07-31

Completion:

2019-11-30

Conditions

• Gestational Diabetes Mellitus

Interventions

• BEHAVIORAL

No Results Yet

NCT02220348 | COMPLETED | PHASE1

7 participants

A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide Therapeutically

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-07-31

Completion:

2019-05-31

Conditions

• Breast Feeding
• Constipation
• Irritable Bowel Syndrome

Interventions

• DRUG

No Results Yet

NCT02154776 | COMPLETED | PHASE1

13 participants

Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-06-27

Completion:

2016-10-26

Conditions

• Advanced or Metastatic Breast Cancer

Interventions

• DRUG

No Results Yet

NCT02152943 | COMPLETED | PHASE1

37 participants

Everolimus, Letrozole and Trastuzumab in HR- and HER2/Neu-positive Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-07-17

Completion:

2020-12-14

Conditions

• Advanced Malignant Solid Neoplasm
• Estrogen Receptor Positive
• HER2/Neu Positive
• Postmenopausal
• Premenopausal
• Progesterone Receptor Positive
• Recurrent Breast Carcinoma
• Refractory Breast Carcinoma
• Refractory Hormone Receptor Positive Breast Carcinoma
• Stage IIIA Breast Cancer AJCC v7
• Stage IIIB Breast Cancer AJCC v7
• Stage IIIC Breast Cancer AJCC v7
• Stage IV Breast Cancer AJCC v6 and v7

Interventions

• DRUG
• OTHER
• BIOLOGICAL

No Results Yet

NCT02096276 | COMPLETED

1517 participants

Boostrix® Pregnancy Registry

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2014-03-31

Completion:

2019-08-02

Conditions

• Pertussis

Interventions

• OTHER

Results Available

NCT02083965 | COMPLETED | PHASE1

19 participants

Pharmacokinetics of rFVIIIFc at Two Vial Strengths

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-03-31

Completion:

2014-10-31

Conditions

• Severe Hemophilia A

Interventions

• BIOLOGICAL

Results Available

NCT02082210 | COMPLETED | PHASE1/PHASE2

97 participants

A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-03-07

Completion:

2017-12-05

Conditions

• Advanced Cancer
• Gastric Adenocarcinoma
• Gastroesophageal Junction Adenocarcinoma
• Hepatocellular Cancer
• Renal Cell Carcinoma
• Non-Small Cell Lung Cancer

Interventions

• DRUG

Results Available

NCT02035605 | COMPLETED | PHASE1

51 participants

A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-01-20

Completion:

2017-07-20

Conditions

• Hemophilia A
• Hemophilia B

Interventions

• DRUG

No Results Yet

NCT01968915 | COMPLETED | PHASE1

9 participants

Safety and Tolerability of Oral LCL161 in Japanese Adult Patients With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-11-30

Completion:

2015-06-30

Conditions

• Neoplasms

Interventions

• DRUG

No Results Yet

NCT01950481 | COMPLETED | PHASE1

36 participants

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2014-01-31

Completion:

2016-09-30

Conditions

• Normal Hepatic Function
• Impaired Hepatic Function

Interventions

• DRUG

No Results Yet

NCT01898845 | COMPLETED | PHASE1

17 participants

A Phase I Study of LEE011 in Asian Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-05-31

Completion:

2015-01-31

Conditions

• Advanced Solid Tumors

Interventions

• DRUG

No Results Yet

NCT01854606 | COMPLETED | PHASE1

31 participants

Safety and Efficacy of AEB071 and EVEROLIMUS in Patients With CD79-mutant or ABC Subtype Diffuse Large B-Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-12-05

Completion:

2016-06-01

Conditions

• CD79 Mutant or ABC-subtype Diffuse Large B-Cell Lymphoma

Interventions

• DRUG

No Results Yet

NCT01852279 | COMPLETED | NA

15 participants

BCI and FES for Hand Therapy in Spinal Cord Injury

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-05-08

Completion:

2018-12-31

Conditions

• Spinal Cord Injury

Interventions

• DEVICE

No Results Yet

NCT01822613 | COMPLETED | PHASE1

48 participants

Study of Safety & Efficacy of the Combination of LJM716 & BYL719 in Patients With Previously Treated Esophageal Squamous Cell Carcinoma (ESCC)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-07-26

Completion:

2016-06-03

Conditions

• Esophageal Squamous Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT01772797 | COMPLETED | PHASE1

22 participants

Phase Ib Study of LDK378 and AUY922 in ALK-rearranged Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-06-30

Completion:

2016-01-31

Conditions

• Anaplastic Lymphoma Kinase (ALK)
• Non-small Cell Lung Cancer

Interventions

• DRUG

No Results Yet

NCT01769768 | COMPLETED | PHASE1

114 participants

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-04-30

Completion:

2016-08-31

Conditions

• Advanced Solid Tumor

Interventions

• DRUG

No Results Yet

NCT01764776 | COMPLETED | PHASE1

33 participants

Effect of Hepatic Impairment on LDE225..

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-03-31

Completion:

2015-03-31

Conditions

• Normal Hepatic Function
• Impaired Hepatic Function

Interventions

• DRUG

No Results Yet

NCT01730248 | TERMINATED | PHASE1

63 participants

A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-12-18

Completion:

2017-09-28

Conditions

• Myelofibrosis

Interventions

• DRUG

No Results Yet

NCT01634763 | COMPLETED | PHASE1

22 participants

Study of Safety and Preliminary Efficacy for LDK378 in Japanese Patients With Genetic Alterations in Anaplastic Lymphoma Kinase (ALK)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-06-30

Completion:

2016-01-31

Conditions

• Tumors Characterized by Genetic Alterations in Anaplastic Lymphoma Kinase (ALK)

Interventions

• DRUG

No Results Yet

NCT01624636 | TERMINATED | PHASE2

1 participants

Safety and Tolerability of Intravenous LFG316 in Wet Age-related Macular Degeneration (AMD).

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-12-31

Completion:

2013-05-31

Conditions

• Neovascular Age-related Macular Degeneration

Interventions

• DRUG

No Results Yet