Helicobacter Pylori Genome Project (HpGP)

Summary

Helicobacter pylori is a common bacterial infection. It can lead to severe stomach problems, including stomach cancer. Researchers want to look at samples of the bacteria. These H. pylori strains will be taken from chronically infected people. They want to identify the genetic and epigenetic differences in H. pylori strains. This could help predict which people who get infected with the bacteria will get stomach cancer. This could lead to the cancer being detected earlier. It could also mean less people get stomach cancer.

Objectives:

To study genetic variations of H. pylori strains based on samples from chronically infected people. To identify the features of strains that might lead to severe stomach problems or stomach cancer.

Eligibility:

People ages 30-70 years who need an upper endoscopy or who were recently diagnosed with stomach cancer

Design:

Participants will be screened by the doctor who does their procedure and a study nurse.

Participants who have endoscopy will have \~6 biopsies removed. These are tissue samples. They are about the size of a grain of rice. Participants will allow the study team to access reports from their stomach exam.

Participants with stomach cancer will donate some of the tissue that will be removed during their clinical care. They will allow the study team to access reports of their surgery. They will also allow them to access the microscope slides of their stomach.

Conditions

• Gastric Cancer
• Non-Atrophic Gastritis
• Intestinal Metaplasia

Sponsors & Collaborators

• New England Biolabs, USA

  collaborator UNKNOWN

• National Institute of Infectious Diseases, Japan

  collaborator UNKNOWN

• National Institute of Genetics, Japan

  collaborator UNKNOWN

• Chiba University, Japan

  collaborator UNKNOWN

• National Institute for Basic Biology, Japan

  collaborator UNKNOWN

• Instituto Mexicano del Seguro Social

  collaborator OTHER_GOV

• Universidade de Lisboa, Portugal

  collaborator UNKNOWN

• Instituto de Biomedicina de Valencia, Spain

  collaborator UNKNOWN

• University of Bath, UK

  collaborator UNKNOWN

• Vanderbilt University Medical Center, USA

  collaborator UNKNOWN

• Karolinska Institutet

  collaborator OTHER

• University of Tokyo, Japan

  collaborator UNKNOWN

• Max von Pettenkofer-Institute of Hygiene and Medical Microbiology, Germany

  collaborator UNKNOWN

• Universidad de Chile, Chile

  collaborator UNKNOWN

• HOSEI University, Japan

  collaborator UNKNOWN

• National Cancer Institute (NCI)

  lead NIH

Principal Investigators

• Charles S. Rabkin, M.D. · National Cancer Institute (NCI)

• M. Constanza Camargo, Ph.D. · National Cancer Institute (NCI)

Eligibility

Min Age

30 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-07-27

Primary Completion

2020-05-15

Completion

2020-05-15

Countries

• United States
• Algeria
• Argentina
• Bangladesh
• Belgium
• Brazil
• Bulgaria
• Burma
• Cameroon
• Canada
• Chile
• Colombia
• Costa Rica
• Democratic Republic of the Congo
• Dominican Republic
• France
• Germany
• Ghana
• Greece
• Guatemala
• Honduras
• Iceland
• India
• Indonesia
• Iran
• Israel
• Italy
• Japan
• Jordan
• Kazakhstan
• Kenya
• Kyrgyzstan
• Latvia
• Lithuania
• Malaysia
• Mexico
• Nepal
• Nigeria
• Peru
• Poland
• Portugal
• Puerto Rico
• Russia
• Singapore
• South Africa
• South Korea
• Spain
• Sudan
• Sweden
• Switzerland
• Taiwan
• Turkey (Türkiye)
• Vietnam

Study Locations