Clinical Trials

NCT01764776 | COMPLETED | PHASE1

33 participants

Effect of Hepatic Impairment on LDE225..

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2013-03-31

Completion:

2015-03-31

Conditions

• Normal Hepatic Function
• Impaired Hepatic Function

Interventions

• DRUG

No Results Yet

NCT01730248 | TERMINATED | PHASE1

63 participants

A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-12-18

Completion:

2017-09-28

Conditions

• Myelofibrosis

Interventions

• DRUG

No Results Yet

NCT01634763 | COMPLETED | PHASE1

22 participants

Study of Safety and Preliminary Efficacy for LDK378 in Japanese Patients With Genetic Alterations in Anaplastic Lymphoma Kinase (ALK)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-06-30

Completion:

2016-01-31

Conditions

• Tumors Characterized by Genetic Alterations in Anaplastic Lymphoma Kinase (ALK)

Interventions

• DRUG

No Results Yet

NCT01624636 | TERMINATED | PHASE2

1 participants

Safety and Tolerability of Intravenous LFG316 in Wet Age-related Macular Degeneration (AMD).

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-12-31

Completion:

2013-05-31

Conditions

• Neovascular Age-related Macular Degeneration

Interventions

• DRUG

No Results Yet

NCT01613976 | COMPLETED | PHASE1

10 participants

A Phase Ib Study of Panobinostat (LBH589) in Combination With 5-Azacitidine for Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML) or Acute Myeloid Leukemia (AML) Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-08-31

Completion:

2014-05-31

Conditions

• Myelodysplastic Syndromes (MDS)
• Chronic Myelomonocytic Leukemia (CMML)
• Acute Myeloid Leukemia (AML)

Interventions

• DRUG

No Results Yet

NCT01613690 | COMPLETED | PHASE1

48 participants

Comparing the Pharmacokinetics, Safety and Tolerability of NVA237 in Renal Impairment

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-06-30

Completion:

2010-11-30

Conditions

• Renal Impairment

Interventions

• DRUG

No Results Yet

NCT01602406 | COMPLETED | PHASE1

64 participants

Phase I Study LJM716 Combined With Trastuzumab in Patients With HER2 Overexpressing Metastatic Breast or Gastric Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-09-21

Completion:

2017-08-02

Conditions

• Advanced HER2-positive Breast Cancer or Gastric Cancer

Interventions

• DRUG

No Results Yet

NCT01598103 | TERMINATED | PHASE2

9 participants

Safety and Efficacy of SAF312 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Lesions

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-01-31

Completion:

2012-09-30

Conditions

• Neurogenic Urinary Bladder
• Neurogenic Bladder Disorder
• Neurogenic Dysfunction of the Urinary Bladder
• Neurogenic Bladder, Uninhibited
• Neurogenic Bladder, Spastic

Interventions

• DRUG

No Results Yet

NCT01598077 | COMPLETED | PHASE1

54 participants

A Phase I Study of LJM716 in Squamous Cell Carcinoma of Head and Neck, or HER2+ Breast Cancer or Gastric Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-07-31

Completion:

2014-03-31

Conditions

• HER2 + Breast Cancer, HER2 + Gastric Cancer, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma
• HER2 + Breast Cancer
• HER2 + Gastric Cancer
• Squamous Cell Carcinoma of Head and Neck
• Esophageal Squamous Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT01594957 | COMPLETED | PHASE1

53 participants

Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-04-30

Completion:

2013-04-30

Conditions

• Hepatic Impairment

Interventions

• DRUG

No Results Yet

NCT01576666 | COMPLETED | PHASE1

120 participants

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-07-31

Completion:

2015-04-30

Conditions

• Dose Escalation
• Safety
• Preliminary Efficacy
• Advanced Solid Tumors
• Metastatic Breast Cancer
• Advanced Pancreatic Adenocarcinoma
• Metastatic Colorectal Cancer
• Recurrent Glioblastoma Multiforme
• Gastric Cancer
• Gastroesophageal Junction Cancer
• Triple Negative Metastatic Breast Cancer
• Hormone Receptor Positive (ER+/PR+, and Her2-) Metastatic Breast Cancer

Interventions

• DRUG

No Results Yet

NCT01558752 | COMPLETED | NA

88 participants

A Clinical Trial of a Metal on Poly Component Versus CORAIL Stem: A Bone Mineral Density Study

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-04-30

Completion:

2019-07-31

Conditions

• Total Hip Arthroplasty

Interventions

• DEVICE

Results Available

NCT01558323 | COMPLETED | PHASE1

58 participants

Pharmacokinetics of LCQ908 in Patients With Renal Impairment

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-05-31

Completion:

2013-03-31

Conditions

• Renal Impairment

Interventions

• DRUG

No Results Yet

NCT01546532 | COMPLETED | PHASE2

118 participants

Renal Hemodynamic Effects of RLX030A in Subjects With Chronic Heart Failure (CHF)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-02-29

Completion:

2012-12-31

Conditions

• Chronic Heart Failure (CHF)

Interventions

• DRUG

No Results Yet

NCT01546428 | COMPLETED | PHASE1

44 participants

A Phase I Study of INC280 in Japanese Patients With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-02-29

Completion:

2016-01-31

Conditions

• Advanced Solid Tumor

Interventions

• DRUG

No Results Yet

NCT01535950 | COMPLETED | PHASE2

43 participants

Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-02-29

Completion:

2013-07-31

Conditions

• Neovascular Age-elated Macular Degeneration (Wet AMD)
• Exudative Macular Degeneration

Interventions

• DRUG

No Results Yet

NCT01487785 | COMPLETED | PHASE1

18 participants

Dose-escalation, and Safety Study of LDE225 and Gemcitabine in Locally Advanced or Metastatic Pancreatic Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-03-31

Completion:

2014-07-31

Conditions

• Pancreatic Cancer

Interventions

• DRUG

No Results Yet

NCT01458106 | COMPLETED | PHASE3

71 participants

Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia A

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-11-30

Completion:

2013-12-31

Conditions

• Hemophilia A

Interventions

• DRUG

Results Available

NCT01454739 | COMPLETED | PHASE3

240 participants

Long-Term Safety and Efficacy of rFVIIIFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia A

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-12-31

Completion:

2017-10-31

Conditions

• Hemophilia A

Interventions

• DRUG

Results Available

NCT01440946 | COMPLETED | PHASE3

30 participants

Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB029, in Previously Treated Pediatric Participants With Hemophilia B

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-06-30

Completion:

2014-11-30

Conditions

• Hemophilia B

Interventions

• DRUG

Results Available

NCT01437735 | COMPLETED | PHASE2

1043 participants

Dose Finding Study for QAW039 in Asthma

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-08-31

Completion:

2013-11-30

Conditions

• Asthma

Interventions

• DRUG

No Results Yet

NCT01430416 | COMPLETED | PHASE1

153 participants

Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-12-20

Completion:

2019-05-22

Conditions

• Uveal Melanoma

Interventions

• DRUG

No Results Yet

NCT01425723 | COMPLETED | PHASE3

120 participants

Long-Term Safety and Efficacy of rFIXFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia B

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-12-08

Completion:

2017-10-31

Conditions

• Severe Hemophilia B

Interventions

• BIOLOGICAL

Results Available

NCT01407003 | COMPLETED | PHASE1/PHASE2

138 participants

Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-06-30

Completion:

2013-02-28

Conditions

• Type 2 Diabetes Mellitus (T2DM)

Interventions

• DRUG

No Results Yet

NCT01402440 | TERMINATED | PHASE1

15 participants

Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-11-30

Completion:

2014-04-30

Conditions

• Diffuse Large B-Cell Lymphoma

Interventions

• DRUG

No Results Yet

NCT01344330 | COMPLETED

108 participants

Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Study Type:

OBSERVATIONAL

Last Updated:

2020-12-19

Start Date:

2012-01-31

Completion:

2017-12-31

Conditions

• Colon Cancer

No Results Yet

NCT01324479 | COMPLETED | PHASE1

131 participants

Study of INC280 in Patients With c-MET Dependent Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2012-02-29

Completion:

2017-07-04

Conditions

• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT01309698 | COMPLETED | PHASE4

24 participants

Drug Interaction of Vildagliptin (LAF237) With Voglibose in Japanese Patients With Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-02-28

Completion:

2011-04-30

Conditions

• Type 2 Diabetes

Interventions

• DRUG

No Results Yet

NCT01266135 | TERMINATED | PHASE2

40 participants

Safety and Efficacy of QAX576 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-12-31

Completion:

2013-04-30

Conditions

• Idiopathic Pulmonary Fibrosis

Interventions

• DRUG

No Results Yet

NCT01253603 | COMPLETED | PHASE2

170 participants

Efficacy, Safety, and Pharmacokinetics of QAW039

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-11-30

Completion:

2011-09-30

Conditions

• Persistent Asthma

Interventions

• DRUG

No Results Yet

NCT01242774 | COMPLETED | PHASE1

46 participants

Safety & Efficacy Study of Oral Panobinostat (LBH589) With Chemotherapy in Patients < 65 Years Old With Acute Myeloid Leukemia (AML)

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-10-31

Completion:

2014-05-31

Conditions

• Acute Myeloid Leukemia (AML)

Interventions

• DRUG

No Results Yet

NCT01240655 | COMPLETED | PHASE1

76 participants

A Study of LCL161 in Combination With Weekly Paclitaxel in Adult Patients With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2011-04-30

Completion:

2015-01-31

Conditions

• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT01232595 | COMPLETED | PHASE2

109 participants

Safety and Efficacy of Multiple Daily Dosing of Oral LFF571 in Patients With Moderate Clostridium Difficile Infections

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-10-31

Completion:

2013-07-31

Conditions

• Moderate Clostridium Difficile Infection

Interventions

• DRUG

No Results Yet

NCT01208831 | COMPLETED | PHASE1

45 participants

An East Asian Study of LDE225

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-10-31

Completion:

2013-10-31

Conditions

• Advanced Solid Tumor Cancers
• Medulloblastoma
• Basal Cell Carcinoma

Interventions

• DRUG

No Results Yet

NCT01130064 | COMPLETED | PHASE2

259 participants

Efficacy of QAX576 in Asthma

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-05-31

Completion:

2012-04-30

Conditions

• Asthma

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT01103037 | TERMINATED | PHASE2

8 participants

Efficacy, Safety and Pharmacokinetics of QAV680 Versus Placebo in Patients With Asthma

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-03-31

Completion:

2010-09-30

Conditions

• Asthma

Interventions

• DRUG

No Results Yet

NCT01069692 | COMPLETED | PHASE3

115 participants

Placebo Versus SBR759 in Lowering Phosphate in Dialysis Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-02-28

Completion:

2010-10-31

Conditions

• Hyperphosphatemia
• Chronic Kidney Disease

Interventions

• DRUG

No Results Yet

NCT01068613 | COMPLETED | PHASE2

62 participants

Safety and Efficacy of Multiple Doses of QAX028 in Chronic Obstructive Pulmonary Disease (COPD) Patients

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-01-31

Completion:

2010-08-31

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

• DRUG

No Results Yet

NCT01058434 | COMPLETED | PHASE2

43 participants

Safety and Efficacy of TKI258 in Relapsed or Refractory Multiple Myeloma Patients, Who Are With or Without t(4;14) Chromosomal Translocation

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2010-05-31

Completion:

2013-02-28

Conditions

• Relapsed or Refractory Multiple Myeloma

Interventions

• DRUG

No Results Yet

NCT01055483 | COMPLETED | PHASE1

59 participants

A Phase Ib, Open-label, Multi-center Dose-finding Study of Oral Panobinostat (LBH589) in Combination With Ara-C and Mitoxantrone as Salvage Therapy for Refractory or Relapsed Acute Myeloid Leukemia

Study Type:

INTERVENTIONAL

Last Updated:

2020-12-19

Start Date:

2009-09-30

Completion:

2012-02-29

Conditions

• Acute Myeloid Leukemia

Interventions

• DRUG

No Results Yet