Study of INC280 in Patients With c-MET Dependent Advanced Solid Tumors
NCT01324479 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 131
Last updated 2020-12-19
Summary
This study will assess the safety and efficacy of INC280 in patients with solid tumors that are refractory to current treatment or for which there is not a current standard of care and whose tumors have dysregulation of the c-MET pathway.
Conditions
Interventions
- DRUG
-
INC280
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmaceuticals
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-02-29
- Primary Completion
- 2017-07-04
- Completion
- 2017-07-04
- FDA Drug
- Yes
Countries
- United States
- Australia
- Canada
- France
- Germany
- Hong Kong
- Israel
- Italy
- Netherlands
- Norway
- Singapore
- South Korea
- Spain
- Taiwan
- Thailand
Study Locations
More Related Trials
-
A Study of INCAGN01876 in Participants With Advanced or Metastatic Solid Tumors
NCT02697591 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies
NCT02712905 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Dose-escalation Study in Subjects With Advanced Malignancies
NCT01195311 ·Status: COMPLETED ·Phase: PHASE1
-
Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors
NCT04774952 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
NCT05836324 ·Status: RECRUITING ·Phase: PHASE1
-
A Safety and Pharmacokinetic Phase I/Ib Study of AMC303 in Patients With Solid Tumours
NCT03009214 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Explore the Safety, Tolerability, and Pharmacokinetics of AMG 305 in Subjects With Advanced Solid Tumors
NCT05800964 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients with Advanced Cancer.
NCT04855929 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 in Participants With Selected Advanced Solid Tumors
NCT04972981 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of IMP4297 in Patients With Advanced Solid Tumors
NCT03508011 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive
NCT05879822 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors
NCT03634982 ·Status: UNKNOWN ·Phase: PHASE1
-
Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
NCT07006727 ·Status: RECRUITING ·Phase: PHASE1
-
A Dose Escalation Study of RO6874813 in Participants With Locally Advanced or Metastatic Solid Tumors
NCT02558140 ·Status: COMPLETED ·Phase: PHASE1
-
DT-9081 Study in Participants With Advanced, Recurrent or Metastatic Solid Tumours
NCT05582850 ·Status: TERMINATED ·Phase: PHASE1
-
Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours
NCT05752552 ·Status: RECRUITING ·Phase: PHASE1
-
An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies
NCT02431260 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
NCT07151040 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
NCT04272034 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 1 Study of OMP-305B83 in Subjects With Solid Tumors
NCT02298387 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Evaluating the Safety of Escalating Doses of DLYE5953A in Patients With Refractory Solid Tumors
NCT02092792 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO5429083 in Patients With Metastatic and/or Locally Advanced, CD44-Expressing, Malignant Solid Tumors
NCT01358903 ·Status: COMPLETED ·Phase: PHASE1
-
Open-Label Study to Assess the Safety/Tolerability in Patients With Solid Tumors
NCT00820560 ·Status: COMPLETED ·Phase: PHASE1
-
An Open-Label Study of a Novel JAK-inhibitor, INCB047986, Given in Patients With Advanced Malignancies
NCT01929941 ·Status: TERMINATED ·Phase: PHASE1
-
Safety of CHIR-258 (TKI258) in Advanced Solid Tumors
NCT01270906 ·Status: TERMINATED ·Phase: PHASE1