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Breath Gases, Gut Flora, and Immunity in Children With Constipation

NCT07797491 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-09-01

No results posted yet for this study

Summary

Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an important role in constipation. However, we still do not fully understand exactly how these bacteria affect constipation in children.

This study aims to explore whether the gases children breathe out-including nitric oxide (NO), hydrogen sulfide (H₂S), hydrogen (H₂), and methane (CH₄)-can tell us something about the bacteria in their guts. By comparing children with constipation to healthy children, we hope to find out:

Whether the gases in their breath are different Whether the types of bacteria in their guts are different Whether there is a relationship between breath gases and gut bacteria If we find clear connections, this could lead to a simple, non-invasive breath test that doctors can use to understand a child's gut health without the need for more invasive procedures.

Conditions

  • Constipation - Functional

Sponsors & Collaborators

  • Ruijin Hospital

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
14 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07797491 on ClinicalTrials.gov