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The Intestinal Dysbacteriosis in the Pathogenesis of Necrotizing Enterocolitis

NCT05619055 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2022-11-16

No results posted yet for this study

Summary

Study Description

The goal of this observational study is to detect intestinal flora and the metabolic products in premature infants diagnosed as necrotizing enterocolitis. The main questions it aims to answer are:

* 1\. Whether there is intestinal flora in the stool of premature infants.
* 2\. Are there dysregulated intestinal flora and their metabolic products in premature infants diagnosed as necrotizing enterocolitis.
* 3\. The detailed role and underlying mechanism of the intestinal dysbacteriosis and the metabolic products in premature infants diagnosed as necrotizing enterocolitis.

Participants, premature infants diagnosed as necrotizing enterocolitis (NEC group), will be asked to collect stool (usually 2 times) for intestinal flora analysis.

If there is a comparison group: Researchers will compare premature infants without necrotizing enterocolitis (control group) to see if their intestinal flora and the metabolic products also changed as their NEC counterparts.

Conditions

  • Necrotizing Enterocolitis of Newborn

Interventions

OTHER

Routine treatment

Antibiotics, intravenous fluids and symptomatic supportive treatment.

Sponsors & Collaborators

  • Zuohui Zhao

    lead OTHER

Principal Investigators

  • Zuohui Zhao, Dr · Shandong First Medical University

Eligibility

Min Age
5 Days
Max Age
2 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-05
Primary Completion
2025-03-31
Completion
2025-03-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05619055 on ClinicalTrials.gov