Clinical Characteristics of Small Intestinal Bacterial Overgrowth in Individuals with Abdominal Distention

Summary

Abdominal distention represents a prevalent clinical manifestation characterized by an unclear etiology and pathogenesis. This symptomatology is frequently observed in various conditions, including small intestinal bacterial overgrowth (SIBO) and abnormal orocecal transit time (OCTT). The utilization of the breath test as a non-invasive diagnostic approach has become widespread in recent years for identifying SIBO and abnormalities in OCTT. In this study, the prevalence of SIBO and OCTT irregularities in individuals presenting with abdominal distention was ascertained through the implementation of the breath test. Furthermore, the correlation between abdominal distention and SIBO/OCTT was analysed to enhance the elucidation of the underlying etiology of abdominal distention. These findings aim to offer valuable insights for refining clinical comprehension and strategies related to the diagnosis and treatment of abdominal distention.

Conditions

• Abdominal Distention

Interventions

DIAGNOSTIC_TEST

Breath test

The concentration of methane and hydrogen in the exhaled gas of patients with Abdominal distention is measured by a breath test to determine the presence of SIBO and abnormal OCTT.

Sponsors & Collaborators

• Qilu Hospital of Shandong University (Qingdao)

  collaborator OTHER

• Jinan Central Hospital

  collaborator OTHER

• Zaozhuang Municipal Hospital

  collaborator OTHER

• Weihai Municipal Hospital

  collaborator OTHER

• Central Hospital of Zibo

  collaborator OTHER

• Weifang People's Hospital

  collaborator OTHER

• Dezhou Hospital Qilu Hospital of Shandong University

  collaborator OTHER

• Binzhou Medical University

  collaborator OTHER

• Qihe Xian Renmin Hospital

  collaborator UNKNOWN

• Shandong University

  lead OTHER

Principal Investigators

• Feixue Chen, MD · Qilu Hospital of Shandong University

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-03-01

Primary Completion

2025-08-01

Completion

2025-08-01

Countries

• China

Study Locations