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Combination of High-flow Nasal Oxygen (Optiflow) and Vibrating Membrane Nebuliser (Aerogen) in the Pre-hospital Setting - Before/After Study

NCT07791992 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2026-08-28

No results posted yet for this study

Summary

The aim of this observational before/after study is to determine how to optimally administer oxygen to patients experiencing an asthma or COPD exacerbation in emergency medical services.

The aim will be to determine which method will achieve the target oxygen saturation objectives: \> 95% in asthma exacerbations and between 88% and 92% (or \> 92% in ambient air or with FiO2 21%) in COPD exacerbations.

The study will compare a group "before" receiving standard care with a nebulizer mask to a group "after" using a combination of a vibrating membrane nebulizer and high-flow nasal oxygen.

Conditions

  • Hypercapnia
  • Asthma Exacerbation
  • COPD Exacerbation

Interventions

DEVICE

Vibrating membrane nebulizer and high-intensity nasal oxygen

Vibrating membrane nebulizer and high-intensity nasal oxygen

DEVICE

nebulizer mask and oxygen therapy of 6 to 9 liters per minute

nebulizer mask and oxygen therapy of 6 to 9 liters per minute

Sponsors & Collaborators

  • Centre Hospitalier Sud Francilien

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2027-10-01
Completion
2027-10-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07791992 on ClinicalTrials.gov