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Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy

NCT07784010 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-08-25

No results posted yet for this study

Summary

This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position. The study aims to determine whether individualized PEEP, selected according to the lowest driving pressure, affects cerebral blood flow and brain oxygenation differently from standard PEEP.

Approximately 45 adult patients undergoing robot-assisted radical prostatectomy will be randomly assigned to receive either individualized PEEP or standard PEEP during general anesthesia. Cerebral blood flow will be assessed noninvasively using transcranial Doppler ultrasound, and brain oxygenation will be monitored using near-infrared spectroscopy. Participants will also undergo brief assessments of attention, cognitive function, delirium, and sedation before and after surgery, with follow-up continuing for up to 48 hours after the operation.

Both ventilation approaches are routinely used in clinical practice, and no experimental drug, device, or additional invasive procedure will be used as part of the study.

Conditions

  • Cerebral Hemodynamics
  • Mechanical Ventilation Strategies
  • Robotic Prostatectomy

Interventions

OTHER

Individualized PEEP Titration

Following a recruitment maneuver, PEEP will be decreased from 15 to 5 cmH2O in 1-cmH2O steps. Respiratory mechanics will be assessed after 12 respiratory cycles at each step, and the PEEP level producing the lowest driving pressure will be selected as the individualized PEEP and maintained.

OTHER

Standard PEEP Group

Following a recruitment maneuver, PEEP will be maintained at a fixed level of 6 cmH2O during mechanical ventilation.

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-19
Primary Completion
2026-11-19
Completion
2026-11-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07784010 on ClinicalTrials.gov