MedTrace Logo

The Effect of Positive End-Expiratory Pressure Levels on Perfusion Index and Neurocognitive Functions in Geriatric Patients

NCT07505550 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2026-04-01

No results posted yet for this study

Summary

With the increasing geriatric population, age-related physiological changes and common comorbidities increase the risk of surgical and anesthesia-related complications in this patient group. Therefore, careful planning of anesthesia management and ventilation strategies is crucial to achieve safe and successful clinical outcomes. Positive end-expiratory pressure (PEEP), one of these strategies, should be applied with careful consideration of the balance between ensuring oxygenation and maintaining cardiovascular stability in geriatric patients. Early detection of hypoperfusion during the intraoperative period is also an important part of perioperative management. To this end, near-infrared spectroscopy (NIRS) is used as a noninvasive monitoring method to assess cerebral oxygenation, while the perfusion index (PI) is used to evaluate peripheral circulation, providing clinicians with valuable information for predicting potential complications. However, one of the most important neurological complications that can occur after surgery in geriatric patients is postoperative cognitive dysfunction (POCD). The Mini-Mental State Examination (MMSE) is widely preferred for assessing cognitive function during the perioperative period due to its ease of application and reliability.

The primary objective of this study is to investigate the effects of different PEEP levels on PI in geriatric patients undergoing laparoscopic cholecystectomy and to reveal changes in neurocognitive function by comparing preoperative and postoperative MMSE scores. Our secondary objectives are to evaluate the effects of PEEP on NIRS values and to analyze the possible relationships between NIRS, PI, hemodynamic parameters, and MMSE scores.

Conditions

  • General Anesthesia
  • Elective Laparoscopic Cholecystectomy

Interventions

OTHER

PEEP levels

78 patients undergoing elective surgery in the General Surgery Operating Room were divided into three groups using a computer-assisted randomization method. Group 5 was ventilated with 5 cmH₂O PEEP, Group 7 with 7 cmH₂O PEEP, and Group 9 with 9 cmH₂O PEEP.

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-02
Primary Completion
2025-08-15
Completion
2025-08-29

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07505550 on ClinicalTrials.gov