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Impact of Sweeteners on the Addictive Threshold of Nicotine

NCT07771725 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-08-31

No results posted yet for this study

Summary

To determine if sucralose, an artificial sweetener, modulates nicotine threshold doses for discrimination, subjective-rewarding effects, and reinforcement in smokers with varying levels of dependence.

Conditions

  • Smoking ( Cigarette)

Interventions

DRUG

Nicotine 0.05 mg/pulse and 0.1 mg/pulse

Nicotine will be used and compared to saline given by IV push by study physician

DRUG

Saline Placebo (0.5mL injection)

Saline will be used compared to the low dose of Nicotine given by IV push by study physician

DIETARY_SUPPLEMENT

sucralose

sweet flavor (sucralose) compared to unsweetened flavor

DIETARY_SUPPLEMENT

Sugar syrup (Placebo)

Unsweetened flavor compared to the sweetened flavor sucralose.

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Yale University

    lead OTHER

Principal Investigators

  • Mehmet Sofuoglu, M.D., Ph.D. · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
59 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2029-09-01
Completion
2029-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07771725 on ClinicalTrials.gov