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Performance of CO2-derived Parameters in Predicting Low Cardiac Output Syndrome

NCT07770386 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 306

Last updated 2026-08-18

No results posted yet for this study

Summary

In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction. This syndrome is responsible for postoperative mortality and morbidity, as well as prolonged hospitalization.

CO2-derived parameters are increasingly used to identify low cardiac output status by the PCO2 gap, or anaerobic metabolism by the Pv-aCO2/Ca-vO2 ratio, particularly in septic shock in adults, with or without hypoxemia. The thresholds proposed as pathological values were a PCO2 gap ≥ 6 mmHg and a Pv-aCO2/Ca-vO2 ratio ≥ 1.4 mmHg/ml. However, these markers have not been studied in depth in patients who have undergone cardiac surgery. In adults, studies have focused on the predictive value of the PCO2 gap and Pv-aCO2/Ca-vO2 on postoperative complications. In the pediatric population following cardiac surgery, only retrospective studies exist, with conflicting results on the correlation between the PCO2 gap and cardiac output, and the PCO2 gap and duration of mechanical ventilation.

This study aims to compare the performance of CO2-derived parameters in predicting LCOS and anaerobic metabolism in children after cardiac surgery with cardiopulmonary bypass.

Conditions

  • Low Cardiac Output Syndrome Bypass Children

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Eligibility

Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-27
Primary Completion
2029-06-27
Completion
2029-07-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07770386 on ClinicalTrials.gov