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The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies

NCT07770126 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-08-18

No results posted yet for this study

Summary

The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions:

1. Functional dyspepsia following the Rome IV criteria
2. Active chronic gastritis, non-H. pylori induced atrophic gastritis, intestinal metaplasia and non-H.pylori gastric dysplasia
3. Gastric cancer, including siewert type 2 and 3 esophagastric junction cancers In addition, patients undergoing bariatric surgery are included as a control group. This study will be conducted using a prospective analysis in the three targeted study populations. Biopsy specimens routinely taken during the medical procedure or via the resected material in patients belonging to the target groups will be used.

Exclusion criteria:

* Patients with a history of H. pylori infection diagnosed by serology, on gastric biopsy, by breath test or on antigen test in stool samples.
* Pregnancy.
* Underage patients (\< 18 years).

Conditions

  • Functional Dyspepsia
  • Gastritis
  • Gastritis Chronic
  • Gastric Cancer (GC)
  • Atrophic Gastritis
  • Intestinal Metaplasia of Gastric Mucosa
  • Dysplasia Stomach
  • Helicobacter Infection
  • NHPH Prevalence

Sponsors & Collaborators

  • University Hospital, Antwerp

    collaborator OTHER

  • Algemeen Ziekenhuis Maria Middelares

    collaborator OTHER

  • General Hospital Groeninge

    collaborator OTHER

  • Universiteit Antwerpen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-24
Primary Completion
2028-03-31
Completion
2028-03-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07770126 on ClinicalTrials.gov