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Bedside NT-proBNP Monitoring in Acute Heart Failure

NCT07762521 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-08-13

No results posted yet for this study

Summary

The goal of this observational study is to investigate the association between dynamic changes in NT-proBNP levels and clinical decongestion status in patients with acute decompensated heart failure (ADHF) receiving guideline-directed standard medical treatment.

The main question it aims to answer is:

Among patients with acute decompensated heart failure treated according to current clinical guidelines, are changes in NT-proBNP levels during hospitalization associated with successful clinical decongestion?

Participants will receive standard-of-care treatment for ADHF according to treating physicians' clinical decisions and current guideline recommendations. During hospitalization, serial NT-proBNP measurements and repeated assessments of congestion status will be performed to evaluate the relationship between NT-proBNP dynamics and the process of decongestion.

This study is purely observational and will not assign treatments or modify clinical management. The findings may improve understanding of the role of NT-proBNP dynamics as a marker of treatment response and provide preliminary evidence for future studies on individualized management of acute heart failure.

Conditions

  • Acute Decompensated Heart Failure (ADHF)

Interventions

OTHER

Serial NT-proBNP Measurement

Serial NT-proBNP measurements will be performed during hospitalization to assess dynamic changes in NT-proBNP levels in patients with acute decompensated heart failure receiving standard guideline-directed medical treatment. NT-proBNP measurements are collected for observational analysis only and will not determine or modify clinical treatment decisions.

Sponsors & Collaborators

  • Mao Chen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-15
Primary Completion
2026-11-30
Completion
2026-12-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07762521 on ClinicalTrials.gov