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Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure

NCT00595738 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2011-07-20

No results posted yet for this study

Summary

The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is not clear. We aim to determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure. We will determine the relationship between cardiac output measured via thermodilution and the Fick equation calculated using concurrent oxygen saturations from the distal PA, central vein, and peripheral vein. We also aim to examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.

Conditions

  • Congestive Heart Failure

Interventions

OTHER

Standard of care therapy for severe decompensated heart failure

Standard of care therapy for severe decompensated heart failure

Sponsors & Collaborators

  • Siemens Molecular Imaging

    collaborator INDUSTRY

  • Critical Diagnostics

    collaborator INDUSTRY

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Thomas J Wang, MD · Massachusetts General Hospital

  • James Januzzi, MD · Massachusetts General Hospital

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-12-31
Primary Completion
2010-08-31
Completion
2011-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00595738 on ClinicalTrials.gov