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The Necessity of Surgery in Patients With mGC Achieving Radiological Response After Conversion Therapy

NCT07757165 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 126

Last updated 2026-08-11

No results posted yet for this study

Summary

The core of this study lies in directly addressing the most pressing clinical uncertainty in the current field: For patients with advanced metastatic gastric cancer who have achieved significant radiological remission after conversion therapy, should the addition of radical surgical intervention on top of the best medical treatment bring clear survival benefits to these patients? Answering this question is of extreme importance and urgency, directly affecting the treatment decisions, quality of life, and survival outcomes of a large number of patients.

Conditions

  • Advanced Metastatic Gastric Cancer

Interventions

PROCEDURE

Surgical radical resection (primary lesion + metastatic lesion)

Surgical radical resection (primary lesion + metastatic lesion)

DRUG

Without surgery, continuing with the original medical treatment

Without surgery, continue with the original medical treatment plan until the disease progresses or intolerable toxicity occurs.

Sponsors & Collaborators

  • Fudan University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2028-10-30
Completion
2030-10-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07757165 on ClinicalTrials.gov