Impact of Linked Color Imaging on Sessile Serrated Lesion Miss Rate

Summary

This prospective, multicenter randomized controlled trial aimed to investigate whether linked color imaging (LCI) could reduce the miss rate of sessile serrated lesions (SSLs) during tandem colonoscopy compared with conventional white-light imaging (WLI).

Conditions

• Colorectal Sessile Serrated Lesion

Interventions

PROCEDURE

WLI Then LCI Withdrawal

Patients in the WLI then LCI withdrawal group first underwent careful endoscopic inspection with white-light imaging (WLI). The endoscopic setting was then switched to linked color imaging (LCI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated.

PROCEDURE

LCI Then WLI Withdrawal

Patients in the LCI then WLI withdrawal group first underwent careful endoscopic inspection with linked color imaging (LCI). The endoscopic setting was then switched to white-light imaging (WLI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated.

Sponsors & Collaborators

• Shunde First People's Hospital of Foshan

  collaborator UNKNOWN

• ZhuHai Hospital

  collaborator OTHER

• Jiangmen Central Hospital

  collaborator OTHER

• Yangjiang People's Hospital

  collaborator OTHER

• Zhongshan Guzhen People's Hospital

  collaborator UNKNOWN

• Sihui Wanlong Hospital

  collaborator UNKNOWN

• The Third People's Hospital of Huizhou

  collaborator OTHER

• Longgang District People's Hospital of Shenzhen

  collaborator OTHER

• Suixi People's Hospital of Zhanjiang

  collaborator UNKNOWN

• Nanfang Hospital, Southern Medical University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-08-31

Primary Completion

2028-11-30

Completion

2029-02-28