Narrow Band Imaging Versus White Light for the Detection and Miss of Sessile Serrated Lesion

Summary

Narrow band imaging(NBI) could improve the detection of colorectal lesions, previous investigations demonstrated its potential in detecting not only colorectal adenoma but non-adenomatous polyps, including sessile serrated lesions. But no randomized controlled trials with NBI versus white light imaging(WLI) have been conducted to give a definitive conclusion with statistically significant differences. Therefore, we performed a multicenter, prospective, back to back, randomized controlled trial to compare sessile serrated lesions detection and miss rate of withdraw by NBI and WLI in colonoscopy.

Conditions

• Colorectal Sessile Serrated Lesion

Interventions

PROCEDURE

WLI Then NBI Withdrawal

Patients in WLI then NBI withdrawal group will first be carefully inspected by white light imaging(WLI), each polyp found should be removed. According to the ESGE guideline of colorectal polypectomy, the lesions which size between 4-9mm should by removed by cold snare. Cold biopsy forceps could be utilized considering the difficulty in resection of flat and diminutive polyps(size ≤ 3mm). Then change to narrow band imaging(NBI) for the second withdraw to detect the lesions which found in second time but not the first.

PROCEDURE

NBI Then WLI Withdrawal

Patients in NBI then WLI withdrawal group will first be carefully inspected by narrow band imaging(NBI), each polyp found should be removed. According to the ESGE guideline of colorectal polypectomy, the lesions which size between 4-9mm should by removed by cold snare. Cold biopsy forceps could be utilized considering the difficulty in resection of flat and diminutive polyps(size ≤ 3mm). Then change to white light imaging(WLI) for the second withdraw to detect the lesions which found in second time but not the first.

Sponsors & Collaborators

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• Yantaishan Hospital

  collaborator UNKNOWN

• The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

  collaborator UNKNOWN

• 900 Hospital of Joint Logistics Support Force of PLA

  collaborator OTHER

• Heilongjiang provincial hospital

  collaborator UNKNOWN

• Ankang Central Hospital

  collaborator OTHER

• Nongken Jiansanjiang People Hospital of Heilongjiang Province

  collaborator UNKNOWN

• Huadong Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Baotou Medical College

  collaborator OTHER

• Qilu Hospital, Shandong University

  collaborator UNKNOWN

• Shandong First Medical University

  collaborator OTHER

• Air Force Military Medical University, China

  collaborator OTHER

• Tengzhou Central People's Hospital

  collaborator OTHER_GOV

• Chongqing General Hospital

  collaborator OTHER

• Haikou People's Hospital

  collaborator OTHER

• Changhai Hospital

  lead OTHER

Principal Investigators

• Zhaoshen Li, MD · Changhai Hospital

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

45 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-02-01

Primary Completion

2024-03-28

Completion

2024-05-28

Countries

• China

Study Locations