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Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction

NCT07738861 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 74

Last updated 2026-07-31

No results posted yet for this study

Summary

Postoperative pain is a common complication following mandibular molar extraction and can negatively affect patient comfort and recovery. Tetracycline is a broad-spectrum antibiotic with anti-inflammatory properties that may reduce postoperative inflammation and pain when applied locally to the extraction socket.

This randomized controlled trial aims to evaluate the effect of intraoperative placement of tetracycline on postoperative pain in patients undergoing surgical extraction of mandibular molars. A total of 74 eligible patients will be randomly assigned to receive either intrasocket tetracycline or no local medicament following tooth extraction. All participants will receive the same standard postoperative care and analgesic regimen. Postoperative pain will be assessed using the Visual Analog Scale (VAS) at 24 hours, 48 hours, and 7 days after surgery. The findings of this study will provide evidence regarding the effectiveness of local tetracycline in reducing postoperative pain and may help improve postoperative pain management following mandibular molar extraction.

Conditions

  • Postoperative Pain
  • Mandibular Molar Extraction
  • Tooth Extraction

Interventions

DRUG

Tetracycline

Tetracycline (250 mg) mixed with 0.5 mL sterile saline will be placed directly into the extraction socket immediately following surgical extraction of the mandibular molar and before primary wound closure. The intervention is intended to provide localized antimicrobial and anti-inflammatory effects to reduce postoperative pain. All participants will receive identical postoperative analgesics and oral hygiene instructions.

OTHER

No Intrasocket Medicament

Participants will undergo the same standardized surgical extraction procedure without placement of any intrasocket medicament. All participants will receive identical postoperative management, including diclofenac sodium, oral hygiene instructions, and follow-up assessments. This intervention serves as the control for comparison with the tetracycline group.

Sponsors & Collaborators

  • CMH Lahore Medical College and Institute of Dentistry

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-10
Primary Completion
2026-01-23
Completion
2026-06-28

Countries

  • Pakistan

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07738861 on ClinicalTrials.gov