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Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin

NCT04989127 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2024-03-22

No results posted yet for this study

Summary

The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar tooth extraction. The study included a total of 75 patients with impacted mandibular third molar. Patients were evaluated in 5 randomly separated groups. For the first and third group, Platelets Rich Fibrin+ systemic Antibiotics were applied into the tooth socket and for the second and fourth group, Platelets Rich Fibrin + local antibiotics were applied, respectively. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.

Conditions

  • Impacted Wisdom Tooth

Interventions

DIAGNOSTIC_TEST

Diagnosis

All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant.

PROCEDURE

traditional osteotomies

In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap).

BIOLOGICAL

Platelet Rich Fibrin

Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles.

DRUG

Antibiotics, Penicillin

Antibiotics are prescribed for the patients.

DRUG

Analgesic

Analgesics are prescribed for the patients.

DRUG

Antibiotic

Patients with penicillin allergy

Sponsors & Collaborators

  • Ceren Melahat Donmezer

    lead OTHER

Principal Investigators

  • Ceren Melahat Dönmezer · Near East University

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-17
Primary Completion
2021-02-20
Completion
2021-02-21

Countries

  • Cyprus

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04989127 on ClinicalTrials.gov