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Acute Effects of Estradiol Administration on Brain Function During Fear Learning

NCT07737613 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-07-30

No results posted yet for this study

Summary

The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones. This research will focus specifically on postmenopausal female adults, because age-related changes in cognition and declining estrogen levels may contribute to anxiety symptoms and PTSD risk later in life.

Conditions

  • PTSD and Trauma-related Symptoms
  • Cognitive Decline in Older Adults
  • Post Menopausal Women

Interventions

DRUG

estradiol

oral 2mg tablet of estradiol

Sponsors & Collaborators

  • University of Arizona

    lead OTHER

Principal Investigators

  • Ashley Huggins · University of Arizona

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2027-08-31
Completion
2027-12-31
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07737613 on ClinicalTrials.gov