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Estradiol and Intrusive Memories

NCT07419594 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 273

Last updated 2026-02-19

No results posted yet for this study

Summary

The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.

A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls.

This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.

Conditions

  • PTSD
  • Intrusive Memories
  • Intrusion Symptom
  • Trauma
  • Intrusion

Interventions

DRUG

Estradiol Valerate

3mg of Estradiol Valerate pills, administred orally

DRUG

Placebo

Plabo pill

Sponsors & Collaborators

  • Charite University, Berlin, Germany

    lead OTHER

Principal Investigators

  • Katja Wingenfeld, Prof. Dr. · Charite University, Berlin, Germany

  • Stefan Roepke, Prof. Dr. · Charite University, Berlin, Germany

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-08-19
Primary Completion
2027-12-31
Completion
2028-02-29

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07419594 on ClinicalTrials.gov