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Arthroscopic Infrapatellar Fat Pad Release and Mesenchymal Stem Cell Mobilization

NCT07736716 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2026-07-30

No results posted yet for this study

Summary

This prospective, single-center, paired-sample clinical laboratory study evaluated whether controlled mechanical release of the infrapatellar fat pad during knee arthroscopy increases the number of intra-articular cells with a mesenchymal stem cell immunophenotype. The study also evaluated whether the procedure is accompanied by immediate changes in the expression of selected genes associated with inflammation, immunomodulation, and tissue repair.

Adults undergoing knee arthroscopy for meniscal pathology had a 20-mL intra-articular fluid sample collected before manipulation of any intra-articular structure. The infrapatellar fat pad was then gently and selectively shaved for approximately 1 minute using a motorized arthroscopic shaver with the suction turned off. A second 20-mL intra-articular fluid sample was collected immediately after the procedure and before further irrigation or continuation of the planned arthroscopic surgery.

Paired pre-release and post-release samples were analyzed by flowcytometry to quantify cells with a mesenchymal stem cell immunophenotype. Quantitative real-time polymerase chain reaction was performed on the total cellular fraction to assess IL-1β, IL-6, IL-10, TGF-β, and CD24 gene expression. Comparisons were performed within each participant using the paired samples.

Conditions

  • Knee Arthroscopy Surgery
  • Knee Acute and Chronic Pain
  • Meniscal Tears

Interventions

PROCEDURE

Controlled Mechanical Release of the Infrapatellar Fat Pad

After baseline intra-articular fluid sampling, the infrapatellar fat pad was gently and selectively shaved for approximately 1 minute with the motorized arthroscopic shaver suction temporarily turned off. A second intra-articular fluid sample was collected immediately after shaving and before further irrigation. The released tissue was subsequently removed using routine arthroscopic suction and irrigation. No released tissue or cells were intentionally retained in the joint for therapeutic purposes.

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    lead OTHER

Principal Investigators

  • ibrahim a yavuz, MD, PhD · Ankara Bilkent City Hospital, Department of Orthopedics and Traumatology

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-09
Primary Completion
2025-01-10
Completion
2025-01-10

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07736716 on ClinicalTrials.gov