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Beat-to-beat Evaluation of Atrial Pacing to Test Fluid Responsiveness

NCT07730242 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2026-07-28

No results posted yet for this study

Summary

The goal of this observational study is to learn whether atrial pacing-induced preload variation can identify fluid responsiveness in adult patients admitted to the intensive care unit after cardiac surgery.

The main questions it aims to answer are:

Can beat-to-beat atrial pacing induce measurable changes in stroke volume that predict fluid responsiveness? Do stroke volume changes measured by transthoracic echocardiography (LVOT VTI) and arterial waveform analysis identify patients who respond to a 500 mL fluid bolus?

Researchers will compare fluid responders and non-responders, defined by a ≥10% increase in stroke volume after a 500 mL Ringer's lactate fluid bolus, to determine whether pacing-induced hemodynamic changes predict fluid responsiveness.

Participants will:

Undergo a standardized atrial pacing protocol (80-120 bpm in 10 bpm increments) before and after a routine 500 mL Ringer's lactate fluid bolus.

Undergo transthoracic echocardiography and continuous arterial pressure monitoring during the pacing protocol.

Have routine ICU hemodynamic data collected during their admission.

Conditions

  • Evaluate Whether Beat-to-beat Ramped Atrial Pacing is Related to Fluid Responsiveness in Postcardiac Surgery Patients

Interventions

PROCEDURE

Pacing protocol via routinely placed surgical pacemaker wire

A pacemaker wire is routinely placed by the cardiac surgeon after the surgery, as part of the standard care that occurs with every surgery. As part of the study protocol, an atrial pacing protocol is performed, starting with pacing at 80 bpm, then increasing by 10 beats per minute until reaching 120 bpm, followed by a gradual decrease back to 80 bpm. This protocol is repeated after the administration of the 500 mL fluid bolus. Additionally: As part of routine care, the intensivist frequently adjusts the pacemaker in this manner to test its function.

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2027-01-31
Primary Completion
2028-07-31
Completion
2029-01-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07730242 on ClinicalTrials.gov