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Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension

NCT07728643 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-07-27

No results posted yet for this study

Summary

Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.

Conditions

  • Pediatric Hypertension
  • Primary Hypertension
  • Endothelial Dysfunction

Sponsors & Collaborators

  • Osijek University Hospital

    collaborator OTHER

  • Josip Juraj Strossmayer University of Osijek

    lead OTHER

Principal Investigators

  • Ivana Jukić, MD, PhD · Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek

Eligibility

Min Age
6 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2029-04-30
Completion
2029-09-30

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07728643 on ClinicalTrials.gov