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Myocardial Deformation Before and After Birth

NCT04060381 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2023-03-06

No results posted yet for this study

Summary

Knowledge on the changes in myocardial function in the last weeks before birth and during the first year of life is limited. Through fetal and post-natal echocardiography we intend to describe these changes using myocardial tissue recognition techniques (Speckle tracking echocardiography and Tissue Doppler echocardiography) in healthy neonates, born to term of healthy women after uncomplicated pregnancies. We will compare the findings in this cohort to a cohort of neonates born to term of women with severe pre-pregnancy obesity.

Sick neonates in intensive care units with various cardiac and non-cardiac conditions are often exposed to treatment that may affect both their cardiac function and important echo-variables per se. Using echocardiography, we will examine these changes in neonates treated with blood transfusion, catecholamines and in those treated with Ibuprofen due to a haemodynamic significant arterial duct.

Conditions

  • Myocardial Dysfunction
  • Newborn Morbidity
  • Maternal Obesity

Interventions

DRUG

Blood transfusion, Ibuprofen, or epinephrine, norepinephrine or dopamine

Treatment/ intervention given according to standard protocols at the Neonatal Intensive Care Unit

Sponsors & Collaborators

  • Haukeland University Hospital

    lead OTHER

Eligibility

Max Age
3 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-04-04
Primary Completion
2023-12-31
Completion
2025-12-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04060381 on ClinicalTrials.gov