EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders

Summary

The goal of this trial is to learn whether wearable devices and hormone sampling can measure how the body changes during daily-life challenges in adults with endocrine or metabolic disorders. These disorders include conditions such as high blood pressure, adrenal disorders, diabetes, obesity, thyroid disorders, pituitary disorders, and other hormone-related conditions.

The main questions it aims to answer are:

Can wearable devices measure changes in blood pressure, heart rate, sleep, activity, temperature, and glucose during changes in salt intake, meals, fasting, and short exercise? Do these changes differ between people with different endocrine or metabolic disorders? Are wearable devices acceptable and practical for participants to use at home?

There is no comparison group in this study. Each participant will serve as their own comparison by completing different study phases.

Participants will wear study devices at home to measure blood pressure, heart rate, activity, sleep, temperature, and glucose, follow a low-salt diet for about 1 week and then a high-salt diet for about 1 week, using study instructions, complete meal, fasting, and short exercise tasks, give urine and saliva samples, and possibly blood samples, during the study. Optionally wear a hormone sampling device for about 27 hours, complete short questionnaires about symptoms, sleep, physical activity, and their experience using the devices.

The study will help researchers understand whether wearable monitoring can support future diagnosis and care for people with endocrine and metabolic disorders.

Conditions

• Endocrine Disorders
• Hypertension
• Primary Aldosteronism
• Cortisol Excess
• Obesity & Overweight
• Healthy Adult

Interventions

BEHAVIORAL

Sequential Dietary Sodium Modulation

Participants will complete a standardized home and clinic monitoring protocol using wearable devices. The protocol includes low- and high-sodium diet phases, meal and fasting modules, postural and short exercise challenges, and wearable monitoring during routine endocrine functional tests. The study will assess changes in blood pressure, heart rate, glucose, activity, sleep, temperature, and hormone patterns in response to these challenges.

Sponsors & Collaborators

• University Hospital, Zürich

  collaborator OTHER

• University of Zurich

  collaborator OTHER

• Pontificia Universidad Catolica de Chile

  collaborator OTHER

• ETH Zurich (Switzerland)

  collaborator OTHER

• Felix Beuschlein

  lead OTHER

Principal Investigators

• Felix Beuschlein, Prof. Dr. med. · University Hospital, Zürich

• Thomas Uslar, MD; Assistant Professor · Pontificia Universidad Católica de Chile, CETREN-UC / University Hospital Zürich

• Felix Beuschlein, Prof. Dr. med. · University Hospital, Zürich

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-07-03

Primary Completion

2031-08-31

Completion

2036-08-31

Countries

• Switzerland

Study Locations