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Glucocorticoid Long-term Administration: Effect on Cold Induced Energy Expenditure and Resting Metabolic Rate

NCT03949361 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2022-01-25

No results posted yet for this study

Summary

The aim of the study is to investigate whether treatment with glucocorticoids leads to a change in heat production of the human body at mild cold conditions.

Conditions

  • Thermoregulation Impairment

Interventions

DIAGNOSTIC_TEST

Indirect calorimetry

Resting energy expenditure

DIAGNOSTIC_TEST

Skin Temperature

Temperature: supraclavicular, infraclavicular, abdominal, mid-thigh, non-dominant lower arm, middle finger tip, left lower leg, left dorsal foot, ear thermometer

DIAGNOSTIC_TEST

Dual energy X-ray Absorptiometry (DXA)

Body composition

DIAGNOSTIC_TEST

Blood Sampling

thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), HbA1c, Fibroblast growth factor 21 (FGF21)

DIAGNOSTIC_TEST

FDG-PET

Dynamic PET scanning of the neck-region

DIAGNOSTIC_TEST

Capillary glucose

Prior to fluorodeoxyglucose (FDG)-PET in order to avoid hyperglycemia

DIAGNOSTIC_TEST

Biopsy of supraclavicular adipose tissue (optional)

Ultrasound guided biopsy of the supraclavicular adipose tissue

Sponsors & Collaborators

  • ETH Zurich

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Matthias Matthias, PD Dr. med · Klinik Endokrinologie, Diabetes und Metabolismus

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-01
Primary Completion
2021-12-01
Completion
2021-12-01

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03949361 on ClinicalTrials.gov