Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation

Summary

People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner.

The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay.

DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.

Conditions

• Coronary Syndrome, Acute
• Myocardial Infarction
• Coronary Artery Disease
• Cardiovascular Diseases
• Cardiovascular Disease Acute

Interventions

DIAGNOSTIC_TEST

0/3-hour high-sensitivity cardiac troponin algorithm

High-sensitivity cardiac troponin measurements obtained at presentation and 3 hours after the initial sample as part of the conventional diagnostic strategy for suspected acute coronary syndrome.

DIAGNOSTIC_TEST

0/1-hour high-sensitivity cardiac troponin algorithm

High-sensitivity cardiac troponin measurements obtained at presentation and 1 hour after the initial sample as part of the accelerated diagnostic strategy for suspected acute coronary syndrome.

Sponsors & Collaborators

• Bispeberg and Frederiksberg Hospital

  collaborator UNKNOWN

• Hvidovre and Amager Hospital

  collaborator UNKNOWN

• North Zealand (Hillerød) Hospital

  collaborator UNKNOWN

• Nykøbing Falster Sygehus

  collaborator UNKNOWN

• Gødstrup Hospital

  collaborator OTHER

• Regionshospitalet Viborg, Skive

  collaborator OTHER

• Odense Universitetshospital

  collaborator UNKNOWN

• Esbjerg sygehus

  collaborator UNKNOWN

• Aalborg University Hospital

  collaborator OTHER

• Herlev and Gentofte Hospital

  lead OTHER

Principal Investigators

• Manan Pareek, MD, MSc PhD, FAHA, FESC, FACC · Center for Translational Cardiology and Pragmatic Randomized Trials and Department of Cardiology, Herlev and Gentofte Hospital

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-09-01

Primary Completion

2028-09-01

Completion

2029-02-01

Countries

• Denmark

Study Locations