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Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy

NCT07719439 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 76

Last updated 2026-07-22

No results posted yet for this study

Summary

This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in children undergoing elective adenoidectomy, tonsillectomy, or adenotonsillectomy under general anesthesia. HRV will be recorded noninvasively from 30 minutes before surgery until discharge from the post-anesthesia care unit. Serum cytokines will be measured from 3 mL of residual blood obtained after induction of anesthesia. The study aims to identify perioperative physiologic markers associated with a lower or higher risk of adverse events, thereby supporting safer anesthetic planning.

Conditions

  • Heart Rate Monitoring
  • Vagal Bradycardia
  • Adenotonsillar Hypertrophy
  • Tonsillitis; Hypertrophic
  • Adverse Cardiac Event
  • Respiratory Complication
  • Anesthesia

Sponsors & Collaborators

  • Duzce University

    lead OTHER

Principal Investigators

  • Sultan Baran Erkul, PhD · Duzce University

Eligibility

Min Age
5 Years
Max Age
9 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-06-01
Completion
2027-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07719439 on ClinicalTrials.gov