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Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity

NCT07715955 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 98

Last updated 2026-08-12

No results posted yet for this study

Summary

The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or obesity form 20-70 years old. The main question it aims to answer is:

Does the probiotic supplement increase feelings of satiety and alter gut microbiota composition?

Participants will:

* Receive a daily dose of 6 g probiotic supplement (packed in sachets of 3 g) or placebo for 16 weeks.
* Visit the research unit 3 times at baseline, week 8 and week 16 of the intervention for blood draws and delivering fecal samples.
* Keep a study diary to report deviations from their daily habits and fill in food questionnaires.

Conditions

  • Healthy
  • Overweight (BMI > 25)
  • Overweight , Obesity
  • Male
  • Female
  • Adults
  • Satiety and Food Intake
  • Gut Microbiota Modulation

Interventions

DIETARY_SUPPLEMENT

Probiotic supplementation

16-week consumption of 6 g/day of probiotic supplement

OTHER

Placebo

16-week consumption of 6 g/day of placebo

Sponsors & Collaborators

  • Winclove Probiotics B.V.

    collaborator INDUSTRY

  • Maastricht University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-18
Primary Completion
2029-08-18
Completion
2029-08-18

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07715955 on ClinicalTrials.gov