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Arterial Stiffness and Endothelial Function in Heart Failure

NCT07713719 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-07-20

No results posted yet for this study

Summary

Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure.

The study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points:

* At baseline (when Patients are first diagnosed with heart failure).
* After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care.
* After completion of cardiac rehabilitation program as a part of their routine clinical care.

All assessments are non-invasive.

Conditions

Interventions

OTHER

Study Assessment

* Collection of demographic details (age, sex, ethnicity, alcohol consumption, and smoking status) * Collection of previous/existing results from the participants medical records will include the following: * Medical History: Documented diagnoses, comorbidities, and history of cardiovascular conditions. * Concomitant Medications: Details of all current prescribed and over-the-counter medications relevant to their clinical care. * Physical Examination and Vital Signs: Blood pressure, pulse rate, and any other routinely recorded cardiovascular parameters available within their clinical record. All data will be collected only from information already recorded as part of routine clinical care. In addition to these, the participant will undergo the study assessments: Arterial stiffness, endothelial function, Cardiac output response to stress test and Voice recognition.

Sponsors & Collaborators

  • Coventry University

    lead OTHER

Principal Investigators

  • Prithwish Banerjee · University Hospitals Coventry & Warwickshire NHS Trust

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2028-06-30
Completion
2028-06-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07713719 on ClinicalTrials.gov