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A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)

NCT07709000 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-07-16

No results posted yet for this study

Summary

Researchers are looking for new ways to treat people with B-cell cancers. In this trial, researchers will look at chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). These are blood cancers that affect B-cells in the blood, bone marrow, or lymph nodes.

The goals of this trial are to learn about:

* The safety of MK-1045 and if participants tolerate it. Tolerate means participants will receive trial treatment unless they need to stop treatment due to health problems.
* The number of participants who respond. Respond means the number of cancer cells goes down or signs of cancer go away.

Conditions

Interventions

BIOLOGICAL

MK-1045

Intravenous (IV) infusion

DRUG

Acetaminophen (or similar antipyretic)

Oral administration as a premedication

DRUG

Diphenhydramine (or similar antihistamine)

Per approved product label as a premedication

DRUG

Dexamethasone

IV administration as a premedication

BIOLOGICAL

Tocilizumab

IV administration as a rescue medication

BIOLOGICAL

Tocilizumab biosimilar

IV administration as a rescue medication

BIOLOGICAL

Siltuximab

IV administration as a rescue medication

Sponsors & Collaborators

Principal Investigators

  • Medical Director · Merck Sharp & Dohme LLC

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-21
Primary Completion
2033-11-16
Completion
2033-11-16
FDA Drug
Yes

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Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07709000 on ClinicalTrials.gov