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Continuous Versus High Intensity Interval Exercise in Chronic Obstructive Pulmonary Disease

NCT07707271 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2026-07-16

No results posted yet for this study

Summary

Chronic Obstructive Pulmonary Disease (COPD) is characterized by exercise intolerance, which is a prognostic factor of disease severity and mortality and is usually attributed to ventilatory limitations. Emerging evidence indicates that cerebral oxygenation may also be an important contributor, being impaired both at rest and during exercise in COPD patients. Furthermore, abnormal systemic hemodynamic responses and autonomic nervous system (ANS) dysfunction have been observed, which may further impair cerebral oxygenation. The type of exercise training applied in pulmonary rehabilitation (continuous versus interval) appears to influence these mechanisms differently, yet evidence on their impact on cerebral oxygenation in COPD remains scarce. The aim of this study is to compare, for the first time, the acute changes in cerebral oxygenation, CPET parameters, systemic hemodynamic responses, and autonomic responses in patients with COPD who undergo a high-intensity interval aerobic exercise (HIIE) protocol versus a moderate-intensity continuous aerobic exercise (MICE) protocol. These findings will have important clinical implications, as they may guide the choice of the most appropriate exercise modality in pulmonary rehabilitation.

Conditions

Interventions

OTHER

Moderate intensity continuous aerobic exercise (MICE)

Patients will perform a moderate-intensity continuous aerobic exercise (MICE) protocol on a cycle ergometer that includes 20 minutes of cycling at 50%WRpeak.

OTHER

High-intensity interval aerobic exercise (HIIE)

Patients will perform a high-intensity interval aerobic exercise (HIIE) protocol on a cycle ergometer that consists of 12 sets of 60 seconds work at 85% WRpeak followed by 60 seconds of rest.

Sponsors & Collaborators

  • George Papanicolaou Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
CROSSOVER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2027-06-30
Completion
2028-07-31

Countries

  • Greece

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07707271 on ClinicalTrials.gov