Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients

Summary

Aims: To prove the benefits of an specific strength training program in COPD patients compared to those achieved with the traditional endurance training. We will assess which is the proper training modality and which of them is the most beneficial according to the features of the patient to whom it is applied.

Subjects and Methods: We will study 66 patients diagnosed of COPD with a moderate-severe obstruction (FEV1\<60%) and clinically symptomatic. The monitoring will be done for 3 moths. Patients will be differentiated between COPD with "predominant chronic bronchitis" and COPD with "predominant emphysema", with regard to clinical, functional and radiological criteria. After stratification of the sample, patients will be prospectively assigned to three groups of 22 patients each: a) Endurance training group, on cycle ergometer at a workload of 70% VO2max. b) Strength training group, with 5 different weightlifting exercises (4 sets of 6-8 repetitions). c) Mixed training group, with half the time dedicated to each type of training. Training will be developed during 12 weeks, three times per week, in 40 minutes sessions. Analysed variables, at the beginning and at the end of program will be: Chest X-ray, basic blood analyses, electrocardiogram, simple spirometry and bronchodilator test, blood gases, static pulmonary volumes, diffusion measurement and respiratory muscle pressure. Muscle strength will be assessed by means of 1RM test and the Myometer® dynamometer. Using the muscle skeletal ultrasound, we will control changes in muscle fibre size. Maximal and submaximal exercise tests on cycle ergometer will be also performed, so as a walking test (shuttle walking test). At last, we will assess treatment effect on dyspnea (Mahler's test) and quality of life (CRDQ).

Hypothesis: A strength training program would significantly increase peripheral muscle power. This type of training would mainly have effect on the "predominant emphysema" COPD patient, where the important weight lost causes a decrease in muscle strength.

Conditions

• Obstructive Chronic Pulmonary Disease
• Emphysema

Interventions

OTHER

Endurance training

compare the efficacy of endurance, strength, and the combination of strength and endurance exercise training in patients with COPD.

OTHER

Strength training

compare the efficacy of endurance, strength, and the combination of strength and endurance exercise training in patients with COPD.

OTHER

Combined training

compare the efficacy of endurance, strength, and the combination of strength and endurance exercise training in patients with COPD.

Sponsors & Collaborators

• Fondo de Investigacion Sanitaria

  collaborator OTHER

• Hospitales Universitarios Virgen del Rocío

  lead OTHER

Principal Investigators

• Ortega F Ruiz, Doctor · Hospitales Universitarios Virgen del Rocío

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

45 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2003-03-31

Primary Completion

2010-12-31

Completion

2010-12-31

Countries

• Spain

Study Locations