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More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)

NCT07705178 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2026-07-15

No results posted yet for this study

Summary

In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.

Conditions

Interventions

OTHER

QOL assessment, Neuropsychological

QoL assessment by EORTC SURV100, PPR

DIAGNOSTIC_TEST

Spirometry

During this non-invasive test, the subject must breathe against resistance through a mouthpiece.

DIAGNOSTIC_TEST

DLCO measurement

DLCO measurement is a non-invasive pulmonary function test for Pulmonary Diffusion Capacity.

DIAGNOSTIC_TEST

Echocardioraphy

Echocardiography with strain-rate imaging.

DIAGNOSTIC_TEST

MRI

LF-MRI for detection of morphological and functional changes in the lung and heart.

OTHER

Clinical parameters

Recording patient information (Age, Gender, Weight and height, Ethnicity, current medication, measurement of blood pressure and blood oxygen saturation.

DIAGNOSTIC_TEST

Blood samples

Blood samples for further molecular testing regarding epigenetic aging markers and telomere biology parameters.

DIAGNOSTIC_TEST

MSOT

multispectral optoacoustic tomography of musculus gastrocnemius bilaterally for screening of PAD

Sponsors & Collaborators

  • University of Erlangen-Nürnberg Medical School

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
3 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-07-14
Primary Completion
2028-05-31
Completion
2028-10-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07705178 on ClinicalTrials.gov