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Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD

NCT06093334 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 27

Last updated 2024-12-17

No results posted yet for this study

Summary

With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate possible late damage. This study uses morphologic and free-breathing phase-resolved functional low-field (PREFUL) magnetic resonance imaging (MRI) to identify persistent pulmonary toxicity after treatment for childhood acute lymphoblastic leukemia (ALL), Hodgkin's disease (HD) and allogeneic stem cell transplantation. Furthermore, cardiopulmonary testing is performed by means of a pulmonary function test, echocardiography with strain analysis and spiroergometry.

Conditions

Interventions

DIAGNOSTIC_TEST

Low-field magnetic resonance imaging

Imaging of lung parenchyma and function by LF-MRI

DIAGNOSTIC_TEST

Cardiopulmonary testing

Myocardial function (Strain-Analysis by echocardiography) and spiroergometry, capillary blood gases and lactate

DIAGNOSTIC_TEST

Pulmonary testing

Lung function (VC%, FEV1%)

DIAGNOSTIC_TEST

Blood sample

Standard procedures/parameters routinely available in follow-up care after oncological treatment

Sponsors & Collaborators

  • University of Erlangen-Nürnberg Medical School

    lead OTHER

Principal Investigators

  • Axel Karow, MD · Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen

  • Ferdinand Knieling, MD · Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen

  • Rafael Heiß, MD · Institute of Radiology, University Hospital Erlangen

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
5 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-17
Primary Completion
2024-12-09
Completion
2024-12-09

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06093334 on ClinicalTrials.gov