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Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment

NCT07699315 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-07-13

No results posted yet for this study

Summary

This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) .

The findings may help improve pain management strategies during root canal treatment .

Conditions

  • Symptomatic Irreversible Pulpitis

Interventions

DRUG

dexamethasone

participants receive 4mg dexamethasone administered via intraligamental infiltration followed by inferior alveolar nerve block before endodontic treatment of mandibular molars with symptomatic irreversible pulpitis

DRUG

Saline (0.9% NaCl)

participants receive an equivalent volume of normal saline administered via intraligamental infiltration before root canal treatment for symptomatic irreversible pulpitis

Sponsors & Collaborators

  • Watim Medical & Dental College

    lead OTHER

Principal Investigators

  • Dr.Ayesha S Janjua, BDS · Watim Medical and Dental College

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-31
Primary Completion
2026-12-31
Completion
2026-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07699315 on ClinicalTrials.gov