Biomarkers for Post-treatment Control in HIV: International Study of the EU2Cure Research Consortium (Phase I)

Summary

Antiretroviral therapy (ART) has transformed HIV from a deadly disease into a lifelong infection that can be controlled. Nevertheless, in the majority of people living with HIV (PWH), discontinuation of ART results in viral rebound due to a latent proviral reservoir. Rarely, individuals known as post-treatment controllers (PTC) demonstrate prolonged viral control even after ceasing ART. Investigating the underlying mechanisms driving this sustained viral control has been a goal for the HIV research community. However, previous studies have been hindered by the scarcity of PTC cases, thereby restricting the potential for associative and translational research. Consequently, the aim of this study is to collect and meta-analyse the data from prior trials where PTC have been identified, as well as to retrospectively identify PTC from the routine care outside trials in a multicentre, multinational study called EU2Control. The aggregated clinical data, and the already collected material from trials where PWH consented for use in additional studies on HIV, will be analyzed with the goal to identify predictive biomarkers for sustained viral control. This study will be part of the research line on HIV cure from an ongoing collaborative consortium (EU2Cure). The first phase of this research line involves a retrospective cohort for meta-analysis and establishment of a biobank.

Conditions

• HIV

Interventions

OTHER

No Intervention: Observational Cohort

No intervention (observational cohort)

Sponsors & Collaborators

• EU2Cure consortium

  collaborator UNKNOWN

• Radboud University Medical Center

  collaborator OTHER

• European Aids Treatment Group (EATG), Brussels, Belgium

  collaborator UNKNOWN

• University Hospital, Ghent

  collaborator OTHER

• University Ghent

  collaborator OTHER

• Oslo University Hospital

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Institut Pasteur

  collaborator INDUSTRY

• University of Aarhus

  collaborator OTHER

• IrsiCaixa

  collaborator OTHER

• Fundació Lluita contra les Infeccions

  collaborator UNKNOWN

• IRCCS San Raffaele

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• University of Oxford

  collaborator OTHER

• Guy's and St Thomas' NHS Foundation Trust

  collaborator OTHER

• Chelsea and Westminster NHS Foundation Trust

  collaborator OTHER

• Pomeranian Medical University Szczecin

  collaborator OTHER

• Hospital Universitari Vall d'Hebron Research Institute

  collaborator OTHER

• Medical University of Warsaw

  collaborator OTHER

• Centre Hospitalier Universitaire Vaudois

  collaborator OTHER

• Erasmus Medical Center

  lead OTHER

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-10-31

Primary Completion

2027-10-31

Completion

2027-12-31