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A Pilot Study of the VosCryoTM Breathalyser in Lung Cancer

NCT07689968 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2026-07-14

No results posted yet for this study

Summary

CryoPilot is a single-centre pilot study being conducted at Weston Park Cancer Centre in Sheffield, UK. The goal of this pilot study is to determine whether small-volume exhaled breath condensate sample (EBC) obtained via a VosCryo™ breath sample collection device can provide quantifiable and analysable cellular material, including epithelial cells, leukocytes, or exfoliated tumour cells, in patients with late-stage lung cancer. The main question it aims to answer is whether a breath sample can provide the necessary cellular information that could eventually be used for diagnostic purposes.

The secondary objective is to compare the presence and quality of such material with that obtained from healthy relatives who will act as a low-risk control group, to assess whether EBC-based analysis may differentiate between cancerous and non-cancerous states.

As such this pilot study will have two arms:

* Experimental arm: 12 patients with late-stage lung cancer
* Control arm: 12 low-risk relatives of patients with late-stage lung cancer

Participants will be approached during their visit to Weston Park Hospital and asked to provide informed consent, followed by provision of a breath sample.

Conditions

Interventions

OTHER

Expiratory Breath Condensate Collection

Collection of Expiratory Breath Condensate using the VosCryo device

Sponsors & Collaborators

  • University of Sheffield

    collaborator OTHER

  • Sheffield Teaching Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Robin J Young, MBChB MRCP PhD · Sheffield Teaching Hospitals NHS Foundation Trust

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2027-02-01
Completion
2028-02-01

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07689968 on ClinicalTrials.gov