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Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease

NCT00512746 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1569

Last updated 2011-12-21

No results posted yet for this study

Summary

RATIONALE: Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat.

PURPOSE: This randomized clinical trial is studying screening tests or exams to see how well they work compared to usual care in finding early stage lung cancer in current or past smokers with chronic obstructive pulmonary disease.

Conditions

Interventions

OTHER

cytology and cytometry specimen collection procedure

Samples tested and further interventions added if positive

OTHER

Chest x ray

Patients not diagnosed with lung cancer during the course of the study, will be offered an exit chest x-ray after 5 years or sooner if they withdraw from the trial before 5 years. This could help identify a lung cancer that may not have been associated with symptoms earlier.

PROCEDURE

Autofluorescence bronchoscopy

The bronchial tree will be inspected first under white light and then under blue light. All areas that appear abnormal will initially be documented and only sampled when the bronchoscopic examination has been completed.

PROCEDURE

CT scan

All patients with abnormal sputum cytology and/or cytometry will undergo low dose spiral CT without contrast.

Sponsors & Collaborators

  • University College, London

    lead OTHER

Principal Investigators

  • Stephen G. Spiro · University College London Hospitals

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-08-31
Primary Completion
2011-03-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00512746 on ClinicalTrials.gov