MedTrace Logo

Effect of Circadian Rhythm on the Sedative Efficacy and Recovery Quality of Ciprofol General Anesthesia: A Multi-Center Observational Study

NCT07686432 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 480

Last updated 2026-07-07

No results posted yet for this study

Summary

The goal of this multi-center observational study is to learn about the effect of circadian rhythm (morning vs. afternoon surgery) on the sedative efficacy, hemodynamic stability (especially induction-associated hypotension), and recovery quality of ciprofol general anesthesia in adult patients undergoing elective non-cardiac and non-cranial surgery, comparing target-controlled infusion (TCI) and non-TCI administration modes.

The main question it aims to answer is:

Does circadian rhythm (time of surgery: morning vs. afternoon) affect the sedative efficacy, incidence of induction-associated hypotension, and recovery quality of ciprofol general anesthesia? Eligible patients aged 18-65 years with ASA physical status I-II and BMI 18-30 kg/m² undergoing elective general anesthesia for non-cardiac and non-cranial surgery (duration 1-2 hours) will be grouped by anesthesia start time (morning: 08:00-11:00; afternoon: 14:00-17:00) and receive ciprofol induction and maintenance via TCI or non-TCI infusion. Perioperative data including hemodynamic changes, ciprofol dosage, recovery time, and adverse events will be recorded and analyzed.

Conditions

  • Circadian Rhythm
  • Ciprofol
  • Hemodynamic Instability
  • Anesthetics Adverse Reaction

Interventions

OTHER

Surgery commences in the morning.

The morning group was defined as patients whose surgery commenced between 08:00 and 11:00 and concluded by 13:00.

OTHER

Surgery commences in the afternoon.

The afternoon group was defined as patients whose surgery commenced between 14:00 and 17:00 and concluded by 19:00.

Sponsors & Collaborators

  • People's Hospital of Chongqing Liangjiang New Area.

    collaborator UNKNOWN

  • Chongqing Medical University

    collaborator OTHER

  • Jie Chen

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-08
Primary Completion
2027-05-30
Completion
2027-05-30

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07686432 on ClinicalTrials.gov