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Pomegranate Dietary Supplements in AUD and ALD

NCT07678567 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 144

Last updated 2026-07-24

No results posted yet for this study

Summary

The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements. Recent publications have reported that urolithins are the major active metabolites responsible for the beneficial effects of eating pomegranates, berries, or walnuts. However, the production of urolithins from the parent compound ellagic acid (EA) is dependent upon the presence of certain bacteria in the human gut. In this trial, we propose to investigate variations in gut microbiota and their capacity to metabolize pomegranate dietary supplements (PDS) into active urolithins. We will measure the levels of urolithins in blood as well as inflammatory cytokines in plasma samples upon consumption of PDS.

Conditions

Interventions

DIETARY_SUPPLEMENT

Pomegranate Dietary Ssupplement

Nutricost Pomegranate Extract 15,000mg Equivalent from 1,000mg of 15:1 Extract Per Servings, 120 Capsules for 40 Servings Per Bottle - Vegan, GMO Free and Gluten Free;

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    collaborator NIH

  • University of Louisville

    lead OTHER

Principal Investigators

  • Craig J McClain, MD · University of Louisville

  • Vatsalya Vatsalya, MD · University of Louisville

  • Venkatakrishna R Jala, PhD · University of Louisville

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2027-01-01
Primary Completion
2031-06-30
Completion
2032-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07678567 on ClinicalTrials.gov