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Endothelin Role In COronary Microcirculation

NCT07670091 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-06-26

No results posted yet for this study

Summary

Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries. Previous studies suggest that endothelin-1, a naturally occurring substance that causes blood vessel constriction, may contribute to abnormalities in the coronary microcirculation.

The ERICOM study aims to investigate whether treatment with bosentan, an endothelin receptor antagonist, can improve coronary microvascular function in patients with angina and evidence of coronary microvascular dysfunction. Participants undergo cardiovascular magnetic resonance (CMR) imaging before and after treatment, and some participants also undergo invasive coronary physiological assessment.

The results of this study may improve understanding of the role of endothelin-1 in coronary microvascular dysfunction and help identify new treatment strategies for patients with angina and non-obstructive coronary artery disease.

Conditions

  • Coronary Microvascular Dysfunction (CMD)
  • Angina Pectoris With Normal Coronary Arteriogram
  • Microvascular Angina

Interventions

DIAGNOSTIC_TEST

Cardiac MRI

Cardiac stress/perfusion MRI scan

PROCEDURE

Invasive Coronary Angiogram

Invasive Coronary Angiogram with pressure wire assessments

DRUG

Endothelin Receptor Antagonist

Participants will be given PO Bosentan 125 mg BD for 4 weeks.

Sponsors & Collaborators

  • Liverpool University Hospitals NHS Foundation Trust

    lead OTHER_GOV

Principal Investigators

  • Michael Fisher · NHS University Hospitals of Liverpool Group

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-01
Primary Completion
2025-07-31
Completion
2026-08-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07670091 on ClinicalTrials.gov