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iCorMicA - Stratified Medicine in Angina

NCT04674449 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1500

Last updated 2026-04-09

No results posted yet for this study

Summary

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.

Conditions

  • Microvascular Angina
  • Angina, Stable
  • Ischemia With No Obstructive Coronary Arteries (INOCA)
  • Coronary Microvascular Dysfunction (CMD)
  • Ischaemic Heart Disease
  • Non-Obstructive Coronary Atherosclerosis
  • Coronary Artery Disease
  • Vasospastic Angina
  • Coronary; Ischemic
  • Angina Attacks

Interventions

DIAGNOSTIC_TEST

Disclosure of IDP results

The results of the adjunctive IDP performed at time of invasive coronary angiography are made available to the catheter laboratory clinician, to aid in the diagnostic process.

OTHER

IDP performed but results not disclosed

The results of the IDP performed at the time of invasive coronary angiography are concealed from the catheter laboratory clinician who will be blinded. The patient is managed according to standard of care.

Sponsors & Collaborators

  • University of Glasgow

    collaborator OTHER

  • Abbott Medical Devices

    collaborator INDUSTRY

  • NHS Greater Glasgow and Clyde

    lead OTHER

Principal Investigators

  • Colin Berry, MBChB, PhD · University of Glasgow

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-30
Primary Completion
2026-06-30
Completion
2030-12-31

Countries

  • Ireland
  • Netherlands
  • Poland
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04674449 on ClinicalTrials.gov