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Pathological Mechanism Study of Aerobic Exercise Regulating Cold Stress-induced Hypertension Via the Thermosensitive Target-mediated Sympathetic Nerve Pathway

NCT07666607 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-06-24

No results posted yet for this study

Summary

This study focuses on the specificity of thermosensitive targets in populations with hypertension in cold regions, identifies core targets through transcriptome sequencing and clinical validation, and clarifies the regulatory mechanism of moderate-intensity aerobic exercise through a prospective cohort study, providing scientific basis for precise prevention and treatment of hypertension in cold regions and personalized exercise intervention.

Conditions

Interventions

BEHAVIORAL

Exercise exposure

Patients with essential hypertension in cold regions who met the inclusion criteria were prospectively recruited and divided into an exercise exposure group and a non-exercise control group based on their willingness to accept and adhere to the exercise protocol developed for this study, with a follow-up period of 16 weeks. At baseline and the end of follow-up, we measured the expression of core thermosensitive targets, blood pressure (BP), heart rate variability (HRV), as well as the levels of sympathetic neurotransmitters and indicators of the renin-angiotensin-aldosterone system (RAAS), and compared the changes in these indicators between the two groups.

Sponsors & Collaborators

  • Wang Jingfeng

    lead OTHER

Eligibility

Min Age
60 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-04
Primary Completion
2025-12-28
Completion
2025-12-28

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07666607 on ClinicalTrials.gov