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Propolis-Based Solution Application in Extraction Socket Healing

NCT07665814 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2026-06-29

No results posted yet for this study

Summary

This pilot study evaluated whether a propolis-based topical solution improves soft-tissue healing after tooth extraction. Thirteen patients requiring extraction of two comparable teeth on opposite sides of the mouth were enrolled in a split-mouth design, in which one extraction site received the propolis solution while the other served as an internal control. The test site was treated with the propolis solution three times daily for seven days, while the control site received only saline rinses. Healing was tracked using 3D intraoral scans obtained before extraction and on days 7 and 14 afterward, allowing the percentage of socket closure to be measured objectively over time. Postoperative pain was also assessed using a standard visual pain scale on days 1, 3, and 7. The study aimed to determine whether this propolis-based formulation could serve as a natural, low-cost adjunct to standard post-extraction care to support faster tissue repair.

Conditions

  • Healthy

Interventions

DRUG

Propolis-based topical solution (52% propolis extract, clove oil [Eugenia caryophyllus], and white willow bark [Salix alba] extract)

Drug: Propolis-Based Solution "A topical solution (52% propolis extract, clove oil, and white willow bark extract) applied to the test extraction socket via brush applicator three times daily for seven days."

OTHER

Saline rinse (control)

The contralateral extraction socket received saline mouthwash only, with no active therapeutic agent applied, following the same pre-application oral hygiene steps (tooth brushing and saline rinse) as the test site

Sponsors & Collaborators

  • Saint-Joseph University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
8 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2026-04-01
Completion
2026-04-01

Countries

  • Lebanon

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07665814 on ClinicalTrials.gov