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'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial'

NCT07364253 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-02-02

No results posted yet for this study

Summary

The goal of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate. The main question it aims to answer is:

Is propolis-containing gargle safe and effective alternative to chlorhexidine gluconate following impacted third molar surgery? Does propolis demonstrate comparable outcomes in pain control and mouth opening ?

Conditions

  • Third Molar Surgery
  • Post Operative Analgesia

Interventions

PROCEDURE

Third molar Surgery with propolis gargle

The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered a 3% propolis gargle (formulated in an ethanol solution, twice daily for 1 minute, prepared in the Departments of Pharmacology.

PROCEDURE

Third molar surgery with chlorhexidine gluconate

The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered chlorhexidine gluconate (0.12%) gargle, twice daily for 1 minute.

Sponsors & Collaborators

  • Ataturk University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-01-05
Primary Completion
2021-06-03
Completion
2022-01-07

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07364253 on ClinicalTrials.gov